耐药性绒癌2例病例报道及文献复习  

Clinical analysis and literature review in 2 cases of resistant gestational trophoblastic neolpsia

作　　者：刘飞飞[1] 田泉[1] 王丽莎[1] 薛艳[1] 安瑞芳[1] 

机构地区：[1]西安交通大学医学院第一附属医院,陕西西安710061

出　　处：《中国计划生育和妇产科》2015年第12期74-78,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的评价三联化疗方案联合手术治疗耐药/复发性妊娠滋养细胞肿瘤(gestational trophoblastic neolpsia,GTN)的疗效。方法分析西安交通大学医学院第一附属医院妇产科2008年3月和2013年4月收治的2例耐药/复发性绒癌患者病例资料,同时进行相关文献复习。结果 2例经过多疗程化疗,效果不佳,行全子宫切除术,1例低危耐药患者手术前后血β-绒毛膜促性腺激素(human chorionic gonadotropin,β-h CG)下降99.62%,随访30个月;另1例高危耐药患者手术前后血β-h CG下降99.36%,随访7个月;2例随诊期间,均未见复发及转移征象。结论 GTN虽以化疗为主要治疗方法,但对耐药/复发性GTN的患者,化疗联合手术治疗对其预后有重要作用。Objective To investigate the value of combining 5- Fu、MTX 、VP16 regimen with surgery in treatment of resistant/relapsed gestational trophoblastic neolpsia（ GTN）. Methods Clinical data of 2 cases with resistant / relapsed choriocarcinoma patients who received multiple courses of chemotherapy,could not reach good results and have performed hysterectomy in The First Affiliated Hospital of Xi＇an Jiaotong University at March 2008 and April 2013 was analyzed. Results Serum β- h CG of one case with low- risk resistant declined 99. 62 %,followed up for 29 months,no signs of recurrence and metastasis. Serum β- h CG of another one case high- risk resistant declined 99. 36 %,followed up for 6 months,no recurrence. Conclusion Although chemotherapy is as the main treatment method of GTN,surgery combined chemotherapy play an important role in the prognosis for resistant / relapsed patients.

关 键 词：妊娠滋养细胞肿瘤 耐药/复发性 治疗 化疗(三联方案) 手术 

分 类 号：R711.74[医药卫生—妇产科学]