量子点遗传毒性研究进展  

Research advances in genotoxicity of quantum dots

作　　者：何克宇 唐萌[1] 

机构地区：[1]教育部环境医学工程重点实验室东南大学公共卫生学院&苏州纳米科技协同创新中心江苏省生物材料与器件重点实验室,江苏南京210009

出　　处：《中国药理学与毒理学杂志》2015年第6期1014-1020,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(30972504);国家自然科学基金(81172697);国家自然科学基金(81302461);国家自然科学基金(81473003);国家重大科学研究计划项目(2011CB933404);江苏省基础研究计划(自然科学基金BK2011606)~~

摘　　要：有关量子点(QD)的遗传毒性作用研究取得了一定进展。研究显示,QD进入内环境后通过产生活性氧和释放有毒内核离子这两种机制产生遗传毒效应。彗星实验及微核实验表明,QD产生的遗传毒效应主要是DNA损伤和染色体畸变。DNA损伤和染色体畸变的程度受多个影响因素控制:QD浓度越高毒效应越强;QD粒径越小越易进入细胞核并产生遗传损伤;表面带负电荷的QD毒性更强;裸核QD的毒性比外壳包覆的QD毒性强。另外,QD在不改变细胞遗传物质的条件下,通过表观遗传学改变也可产生遗传效应,使有害效应持续存在。The genotoxicity of quantum dots （QDs） has been confirmed by a variety of experi- ments. When QDs are absorbed in an internal environment, genotoxic effects can be induced in two ways. One is through the generation of reactive oxygen species, and the other is via core release. The comet assay and micronucleus test show that the genetic toxicity effects of QDs are DNA damage and chromosome aberrations. The level of QDs＇ genotoxicity can be affected by many factors. It has been observed that more severe genotoxicnity can be caused by QDs of smaller size or in higher concentrations. Negative charges modified QDs often show more significant genetic damage. However shelled QDs can be less harmful or even harmless. Besides, the epigenetic toxicity of QDs can make the adverse effect persistent, even to the next generation, without any genetic damage.

关 键 词：量子点 DNA损伤 活性氧 纳米材料 

分 类 号：R114[医药卫生—卫生毒理学]