高甘油三脂血症-腰围表型与超敏C反应蛋白在糖尿病下肢血管病变中的临床意义  

THE CLININAL SIGNIFICANCE OF THE HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE( HTWP)AND HIGH-SENSITIVITY C-CREACTIVE PROTEIN( hs-CRP)IN TYPE 2 DIABETES WITH THE LOWER LIMB VASCULAR LESION

作　　者：范培云[1] 姚勇利[1] 刘佳佳[2] 李亚楠[1] 罗玮[1] 周环 

机构地区：[1]青海省人民医院糖尿病科 [2]青海大学 [3]北京第二炮兵总院医学影像科

出　　处：《青海医学院学报》2015年第4期260-263,共4页Journal of Qinghai Medical College

基　　金：青海省科学技术厅(应用)基础计划研究项目(2014-ZJ-741)

摘　　要：目的探讨2型糖尿病患者高甘油三脂血症-腰围表型(HTWP)及超敏C反应蛋白(hs-CRP)在下肢血管病变中的意义。方法将66例2型糖尿病患者分成两组:糖尿病合并下肢血管病变组(30例)和无血管病变组(36例)。同时根据甘油三脂及腰围分为高甘油三脂血症-腰围表型组(HTWP组,28例)和非高甘油三脂血症-腰围表型组(非HTWP组,38例),并检测患者糖化血红蛋白(Hb A1c)、超敏c反应蛋白(hs-CRP)及血脂。结果 (1)HTWP组下肢血管病变发生率明显高于非HTWP组,且病变程度更重;(2)下肢血管病变组患者的hs-CRP、TG、LDL-C及体重指数、腰围显著高于无血管病变组,HDL-C明显低于无血管病变组。结论高甘油三脂血症-腰围表型、hs-CRP可作为指标用于糖尿病下肢血管病变的诊断。Objective To investigate the hypertriglyceridemic waist phenotype（ HTWP） and high-sensitivity C-reactive protein（ hs-CRP） in type 2 diabetes with the lower limb vascular lesion. Method A total of 66 patients were divided into T2 DM complicated with lower limb vascular lesion group（ group A,n = 30）,patients with T2 DM group（ group B,n = 36）,at the same time,according to the waist and triglyceride（ TG）,the patients were subdivided into HTWP group and non- HTWP group.Level of serum Hb A1 C,blood lipid and hs-CRP in four groups were determined and compared.Result 1） The incidence and degree of lower limb vascular lesion in HTWP group were significantly higher than that of in the non- HTWP group,2） The level of hs-CRP,BMI,waist diameter,TC,TG and LDL-C in group A were significantly higher than those in the group B,The level of HDL-C in group A are significantly lower than that in the group B.Conslusion The hypertriglyceridemic waist phenotype（ HTWP） and high-sensitivity C-reactive protein（ hs-CRP） may have a certain clinical value for the diagnosis of the lower limb vascular lesion in type 2 diabetes.

关 键 词：高甘油三脂血症-腰围表型 2型糖尿病 超敏C反应蛋白 下肢血管病变 

分 类 号：R473.58[医药卫生—护理学]