利福布汀超短程治疗初次复治涂阳肺结核32例临床研究  

Rifabutin Ultra Short Range Treatment for First Time Retreatment of Smear- Positive Tuberculosis in 32 Cases

作　　者：问亚锋 

机构地区：[1]江苏省淮安市淮安医院,江苏淮安223200

出　　处：《中国药业》2015年第23期63-65,共3页China Pharmaceuticals

摘　　要：目的探讨利福布汀超短程治疗初次复治涂阳肺结核的临床疗效及安全性。方法将初次复治涂阳肺结核患者64例随机分为对照组和观察组,各32例。对照组予复治肺结核标准方案2HREZS/6HRE,全程8个月;观察组予利福布汀超短程方案2HBEZS/6HBE,全程5个月。结果治疗后,观察组临床疗效总有效率为90.62%,明显高于对照组的71.88%(P<0.05);与对照组相比,观察组治疗2,3,4,5月末痰菌转阴率均明显提高,疗程结束时痰菌转阴率为90.62%,明显高于对照组71.88%(P<0.05);观察组病灶吸收、空洞闭合情况较对照组均明显改善(P<0.05);治疗过程中,两组患者不良反应均较轻微(P>0.05)。结论利福布汀超短程治疗初次复治涂阳肺结核患者可提高治愈率,促进患者痰菌转阴,缩短治疗时间,减少耐药肺结核发生的可能性,不良反应轻微。Objective To explore the rifabutin intervention in patients with first time retreatment of smear- positive tuberculosis. Methods64 cases of patients with the first time retreatment smear- positive tuberculosis were randomly divided into the control group and observation group, 32 patients in each group. The control group was treated with retreatment pulmonary tuberculosis to standard chemotherapy 2HREZS / 6HRE for 8 months; the observation group received rifampicin trimebutine ultra short course chemotherapy scheme 2HBEZS / 6HBE for 5 months. Results After treatment, the clinical efficacy of the observation group was 90. 62%, which was significantly higher than 71. 88% of the control group（ P 〈 0. 05）; compared with the control group,the sputum negative conversion rate in the 2,3,4,5 months of the observation group significantly increased,at the end of the treatment,the sputum negative conversion rate was 90. 62% in the observation group,which was significantly higher than 71. 88% of the control group（ P 〈 0. 05）; the focus absorption and cavity closure of the observation group were significantly improved compared with the control group（ P 〈 0. 05）; the adverse reactions of the two groups were mild and there was no significant difference between the groups（ P 〉 0. 05）. Conclusion Rifabutin ultra short range treatment for the first retreatment smear- positive tuberculosis patients can improve the cure rate and promote the sputum negative conversion,shorten treatment time,reduce the possibility of drug resistance pulmonary tuberculosis,qnd the adverse reactions are mild.

关 键 词：利福布汀 初次复治 涂阳肺结核 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R978.3[医药卫生—药学]