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作 者:徐良斌[1]
出 处:《中国药业》2015年第23期67-68,共2页China Pharmaceuticals
摘 要:目的探讨阿奇霉素联合红霉素治疗小儿支原体肺炎的疗效及安全性。方法将160例小儿支原体肺炎患儿随机分为对照组(阿奇霉素)和观察组(阿奇霉素联合红霉素),各80例。比较两组临床疗效及症状改善情况,观察治疗期间的不良反应。结果观察组总有效率为95.00%,明显高于对照组的80.00%(P<0.05);与对照组比较,观察组退热、止咳、肺部罗音消失时间均明显缩短(P<0.05);观察组治疗期间皮疹、局部疼痛、胃肠道反应、肝功损伤等不良反应的发生率均显著降低(P<0.05)。结论阿奇霉素联合红霉素治疗小儿支原体肺炎疗效显著、不良反应少、安全性高,值得临床推广。Objective To study the clinical efficacy and safety of azithromycin combined with erythromycin in treating mycoplasma pneumonia infection in children. Methods 160 children with mycoplasma pneumonia infection from October 2014 to May 2015 were divided into the control group( azithromycin) and the observation group( azithromycin combined with erythromycin) according to the random number method,80 cases in each group. The clinical efficacy, the improvement of clinical symptoms and adverse reactions during the treatment period in the two groups were compared. Results Compared with the control group,the excellent effective rate of the observation group was 95. 00%,which was significantly higher than 80. 00% of the control group( P 〈 0. 05); the disappearance times of fever,cough and pulmonary rales were obviously reduced in the observation group( P 〈 0. 05); the incidences of adverse reactions during the treatment period such as rash,local pain,gastrointestinal tract reaction,liver function damage were significantly decreased in the observation group( P 〈 0. 05). Conclusion For the mycoplasma pneumonia infection children,azithromycin combined with erythromycin has significant efficacy,less adverse reactions and higher safety,which is worthy of clinical wide promotion.
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