胰岛素强化方法治疗成人隐匿性自身免疫性糖尿病老年患者的疗效及其对胰岛β细胞功能的影响  

Effect of Intensive Insulin Therapy on the Elderly Patients With Latent Autoimmune Diabetes Mellitus and Its Effect on the Function of Pancreatic Islet Beta cells

作　　者：李志敏[1] 

机构地区：[1]通化市中心医院,134001

出　　处：《中国卫生标准管理》2015年第31期77-78,共2页China Health Standard Management

摘　　要：目的探讨胰岛素强化方法治疗成人隐匿性自身免疫性糖尿病(LADA)老年患者效果及其对胰岛β细胞功能的影响。方法选取成人隐匿性自身免疫性糖尿病老年患者50例为观察组,取同期收治的老年2型糖尿病患者50例为对照组,给予胰岛素强化方法治疗,统计两组患者治疗前后胰岛素释放水平。结果两组患者治疗后空腹血糖浓度以及糖化血红蛋白含量下降。观察组治疗前后HOMA-IS均低于对照组,餐后2 h胰岛素和C肽水平提升程度小于对照组(P<0.05)。结论胰岛素强化方法治疗老年LADA患者有着良好效果,能够提升胰岛素β细胞功能。Objective To investigate the effect of insulin intensive therapy on the elderly patients with latent autoimmune diabetes mellitus and its effect on pancreatic islet beta cell function. Methods 50 patients with latent autoimmune diabetes in adults were observed,and 50 patients with type 2 diabetes were treated with insulin intensive therapy. The level of insulin release in the two groups was observed before and after treatment.Results Fasting blood glucose levels after treatment in both groups and glycated hemoglobin levels drop. HOMA-before and after the treatment IS observed group were lower than the control group,2 h after meal insulin and C peptide level degree IS less than the control group（P 0.05）. Conclusion The method of intensive insulin therapy in the treatment of elderly patients with LADA has a good effect,and can improve the function of insulin beta cells.

关 键 词：胰岛素强化方法 成人隐匿性自身免疫性糖尿病 胰岛Β细胞功能 

分 类 号：R97[医药卫生—药品]