降钙素原及C反应蛋白对胰腺炎感染早期预测及预后的影响  

Effects of Procalcitonin and C Reactive Protein on Early Prediction and Prognosis of Acute Pancreatitis

作　　者：杨怡莎[1] 黎文华[1] 倪景斌[1] 

机构地区：[1]南京医科大学附属无锡第二医院消化科,214002

出　　处：《中国卫生标准管理》2015年第31期148-149,共2页China Health Standard Management

摘　　要：目的探讨降钙素原(PCT)及C反应蛋白(CRP)对胰腺炎感染早期预测及预后的影响。方法选取82例急性重症胰腺炎患者,入院后进行APACHE II评分、测定血清PCT及CRP,根据临床症状、实验室检查结果及微生物学检测结果评估是否存在感染,动态观察患者病情预后,分析结果。结果合并感染者51例,占62.20%,死亡15例,死亡率18.07%,感染与未感染患者死亡率分别为25.49%、6.45%,比较差异有统计学意义(P<0.05);确诊感染的患者入院时PCT、CRP水平及APACHE II评分高于未感染患者(P<0.05),死亡患者入院时PCT、CRP水平及APACHE II评分高于未死亡患者(P<0.05)。结论胰腺炎合并感染、预后不佳的患者早期血清PCT及CRP即可表现为异常升高,检测PCT及CRP对早期预测胰腺炎感染及预后有积极意义。Objective To investigate the effect of procalcitonin（PCT）and C reactive protein（CRP）on the early prediction and prognosis of acute pancreatitis infection. Methods 82 cases of acute severe pancreatitis were selected,II APACHE score,serum PCT and CRP were measured after admission,according to clinical symptoms,laboratory tests and microbiological examination results evaluating whether there was infection,dynamic observation of patients prognosis,analysis results. Results Combined infection 51 cases（62.20%）,15 cases died,the mortality was 18.07%,mortality of infected and uninfected patients were 25.49%,6.45%,the difference was statistically significant（P 0.05）,patients diagnosed with infection on admission,PCT,CRP levels and APACHE II score higher than uninfected patients（P 0.05）,and death patients on admission,PCT,CRP levels and APACHE II score higher than surviving patients（P 0.05）. Conclusion Pancreatitis combined infection and patients with poor prognosis with early serum PCT and CRP can be expressed as abnormal increase,and the detection of PCT and CRP has positive significance for early prediction of acute pancreatitis infection and prognosis.

关 键 词：胰腺炎 感染 降钙素原 C反应蛋白 预测 预后 

分 类 号：R446[医药卫生—诊断学]