磺酸化-β-环糊精为手性选择剂分离5种β-受体阻断剂类药物  

Enantioseparation of five β-blockers with sulfated-β-cyclodextrin as chiral seletor

作　　者：王兆昆[1] 赵龙山[1] 崔智[1] 严加高[2] 郭兴杰[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]辽宁社会科学院,辽宁沈阳110031

出　　处：《沈阳药科大学学报》2015年第12期962-966,共5页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81273476)

摘　　要：目的建立高效毛细管电泳法分离索他洛尔、贝凡洛尔、美托洛尔、普萘洛尔和阿替洛尔5种β-受体阻断剂药物的对映体。方法采用未涂层的熔融毛细管柱,以磺酸化-β-环糊精(sulfated-β-cyclodextrin,S-β-CD)为手性选择剂,磷酸盐缓冲液为背景电解质,分离电压20 k V。结果在最佳条件下,5种药物均得到完全分离,分离度分别为6.7、5.2、1.7、3.1和1.6。结论 S-β-CD对5种药物具有较好的对映体选择性。Objective To separate the enantiomers of five β-blockers-sotalol,bevantolol,metoprolol,propranlol and atenolol by capillary electrophoresis with sulfated-β-cyclodextrin（ S-β-CD） as chiral selector.Methods The separaion of the enantiomers was performed in a fused-silica capillary tube,in the buffer of of Na H2PO4 with the voltage of ± 20 k V. S-β-CD content,buffer p H and concentration were studied and optimized. Results Baseline separation of the five drugs was achieved under the optimized conditions. The resolutions of the five drugs were 6. 7,5. 2,1. 7,3. 1 and 1. 6,respectively. Conclusions It is proved that S-β-CD is a good selector for the separation of the five drugs.

关 键 词：磺酸化-β-环糊精 Β-受体阻断剂 对映体分离 

分 类 号：R917[医药卫生—药物分析学]