IκB-α、MMP-9在食管癌中的表达及其生物学意义  

Expressions of IκB-α and MMP-9 in Esophageal Cancer and Its Biological Significance

作　　者：刘亮[1] 王莉[1] 倪晓辰[1] 武中林[1] 王光大[1] 赵阳[1] 左静[1] 王静[1] 左连富[1] 

机构地区：[1]河北医科大学第四医院肿瘤研究所流式细胞室,石家庄050011

出　　处：《解放军医药杂志》2015年第12期32-35,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的检测核因子κB(NF-κB)的抑制蛋白α(inhibitor of NF-κBα,IκB-α)及基质金属蛋白酶9(matrix metalloprotein-9,MMP-9)在不同食管病变组织中的表达,探讨IκB-α、MMP-9与食管癌发生、发展及转移的关系。方法通过免疫组织化学检测食管鳞癌、食管不典型增生组织及食管正常黏膜组织中IκB-α、MMP-9蛋白的表达;分析食管鳞癌组织中IκB-α、MMP-9蛋白表达与不同临床病理特征的关系,并对食管鳞癌组织中IκB-α与MMP-9蛋白表达相关性进行分析。结果食管鳞癌组织中IκB-α蛋白的表达(80.0%)明显高于食管不典型增生组织(52.3%)及食管正常组织(8.3%),差异有统计学意义(P<0.05),且与淋巴结转移及浸润深度有关。MMP-9蛋白在食管鳞癌组织中的表达(73.3%)明显高于食管不典型增生组织(71.4%)及食管正常组织(16.7%),差异有统计学意义(P<0.05),且与细胞分化程度、淋巴结转移及浸润深度有关。食管癌组织中IκB-α与MMP-9蛋白表达差异无统计学意义(P>0.05)。结论 IκB-α、MMP-9蛋白在食管癌组织中异常表达,参与了食管癌浸润、转移的发生。Objective To detect the expressions of inhibitor of NF-κB α（ IκB-α） and matrix metalloprotein-9（ MMP-9） protein of nuclear factor kappa B（ NF-κB） in different esophageal lesion tissues and to explore the relationship between IκB-α and MMP-9 expressions and pathogenesy,development and metastasis of esophageal cancer. Methods The IκB-α and MMP-9 protein expressions in esophagus squamous cell carcinoma,esophageal atypical hyperplasia and normal esophageal tunica mucosa tissues were detected using immunohistochemistry method; the relationship between the IκB-α and MMP-9 protein expressions in tissues of esophagus squamous cell carcinoma and different clinicopathological features were analyzed as well as the relationship between IκB-α and MMP-9 expressions in tissues of esophagus squamous cell carcinoma. Results The IκB-α protein expression in tissues of esophagus squamous cell carcinoma（ 80. 0%） was significantly higher than 52. 3% in tissues of esophageal atypical hyperplasia and 8. 3% in normal esophageal tissues,and the differences were statistically significant（ P〈0. 05）,and the differences were related to lymph node metastasis and invasion depth. The MMP-9 protein expression in tissues of esophagus squamous cell carcinoma（ 73. 3%） was significantly higher than 71. 4% in tissues of esophageal atypical hyperplasia and 16. 7% in normal esophageal tissues,and the differences were statistically significant（ P〈0. 05）,and the differences were related to cell differentiation degree,lymph node metastasis and invasion depth. IκB-α and MMP-9 protein expressions in esophageal cancer tissues did not have significant correlation（ P〉0. 05）. Conclusion The abnormal expressions of IκB-α and MMP-9 protein in esophageal cancer is involved in the invasion and metastasis of esophageal cancer.

关 键 词：食管鳞状细胞癌 免疫组织化学 基质金属蛋白酶 浸润 转移 

分 类 号：R735.1[医药卫生—肿瘤]