轻度支气管肺发育不良儿童的发育及脉冲振荡肺功能研究  

A Study on Physical Development and Pulmonary Function by Impulse Oscillometry in Children with Mild Bronchopulmonary Dysplasia

作　　者：王淑玉[1] 吕朝霞[1] 郑一博[1] 

机构地区：[1]解放军白求恩国际和平医院儿科,石家庄050082

出　　处：《解放军医药杂志》2015年第12期82-85,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省计划生育委员会科研课题资助项目(2012-C01)

摘　　要：目的监测轻度支气管肺发育不良（bronchopulmonary dysplasia,BPD）儿童3～5岁脉冲振荡肺功能气道阻力及体格发育的动态变化,探讨BPD对患儿远期肺功能和生长发育的影响。方法收集14例轻度BPD患儿（BPD组）3～5岁临床资料,监测身高体重变化,使用Master Screen系列肺功能测定系统做脉冲振荡肺功能（IOS）检查,与同胎龄未合并BPD早产儿20例（对照组）比较。BPD组13例、对照组10例3岁时行高分辨CT（HRCT）检查。结果 3、4、5岁BPD组与对照组体重和身高比较,差异无统计学意义（P〉0.05）。IOS检测提示呼吸总阻抗（Zrs）,总气道阻力（R5）,周边弹性阻力（X5）在BPD患儿中明显升高,与同龄非BPD对照组对比,差异有统计学意义（P〈0.01）;中心气道阻力（R20）与同龄非BPD对照组比较差异无统计学意义（P〉0.05）。BPD组有10例患儿3岁时HRCT有影像学异常,对照组10例中均无异常。结论轻度BPD可导致学龄前儿童肺功能明显异常。Objective To monitor the dynamic changes of pulmonary function airway resistance by impulse oscillometry and physical development in 3-5 year-old children with mild bronchopulmonary dysplasia（ BPD）,and to investigate the effects of BPD on long-term pulmonary function and physical development. Methods Clinical data of 14 3-5year-old children with mild BPD（ BPD group） was collected,and the changes of body height and weight were monitored,pulmonary functions by impulse oscillometry（ IOS） were detected using Master Screen lung function measurement system. The values were compared with those of 20 premature infants at the same fetal age without BPD（ control group）.The high-resolution CT（ HRCT） was performed for 13 children in BPD group and 10 children in control group at the age of 3. Results There were no significant differences in body height and weight between BPD group（ at the age of 3,4and 5） and control group（ P〈0. 05）. IOS detection showed that total respiratory impedance（ Zrs）,total airway resistance（ R5） and peripheral reactance（ X5） values were significantly increased in BPD children,and the difference were statistically significant compared with those in control group（ P〈0. 01）; there were no significant differences in the value of R20 between the two groups（ P〉0. 05）. The abnormal HRCT imaging was found in 10 children of BPD group,and there was no abnormality in the 10 children of control group. Conclusion Mild BPD can obviously induce abnormal pulmonary function of preschool age children.

关 键 词：支气管肺发育不良 儿童 脉冲振荡 肺功能 

分 类 号：R72[医药卫生—儿科] R563.9[医药卫生—临床医学]