急性冠脉综合征患者PCI术后超敏C反应蛋白、脑钠肽水平的预后价值  

Prognosis values of high sensitivity C-reactive protein and brain natriuretic peptide in patients with acute coronary syndrome after percutaneous coronary intervention

作　　者：程小兵[1] 潘文博[1] 钟万生 杨玉雯[2] 徐承华[3] 

机构地区：[1]合肥市第三人民医院心内科安徽医科大学合肥第三临床学院,合肥232000 [2]皖南医学院第一附属医院心内科 [3]安徽中医药高等专科学校附属医院心内科

出　　处：《中国循证心血管医学杂志》2015年第6期839-842,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 探讨急性冠状动脉综合征（ACS）患者经皮冠状动脉介入（PCI）术后血浆脑钠肽（BNP）和超敏C反应蛋白（hs-CRP）水平与临床预后的关系。方法 纳入2012年10月至2014年1月合肥市第三人民医院心内科收治的ACS且行PCI治疗的患者120例。入院后根据血浆BNP和hs-CRP水平分组。分别于PCI术后3-5 d、术后1个月、3个月行超声心动图检查,测量左室射血分数（LVEF）、左室舒张末期内径（LVEDD）,左室舒张末期容积（LVEDV）,左室收缩末期容积（LVESV）等指标。对患者住院期间、PCI术后30 d、术后3个月病死率及主要心脏不良事件（MACE）发生率和心功能进行随访。结果 ACS患者病死率和MACE事件发生率随血浆BNP、hs-CRP水平的升高呈明显递增趋势（P〈0.05）,血浆BNP水平与LVEF呈负相关（r=-0.782,P〈0.001）,与血清hs-CRP呈正相关（r=0.736,P〈0.001）。结论 hsCRP、BNP对ACS行PCI治疗患者的预后有一定的指导意义。Objective To discuss the relationship among brain natriuretic peptide（BNP）, high sensitivity C-reactive protein（hs-CRP） and clinical prognosis in patients with acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods ACS patients undergone PCI（n=120） were chosen from Oct. 2012 to Jan. 2014, and divided into groups according to levels of plasma BNP and hs-CRP. All groups were given examinations of echocardiogram for detecting LVEF, LVEDd, LVEDV and LVESV after PCI for 3-5 d, 1 m and 3 m respectively. The mortality, incidence of major adverse cardiovascular events（MACE） and heart function were followed up during hospitalization and 30 d and 3 m after PCI. Results The mortality and incidence of MACE showed a significant ascending trend as BNP and hs-CRP increased in ACS patients（P〈0.05）. BNP was negatively related to LVEF（r=-0.782, P〈0.001）, and positively related to hs-CRP（r=0.736, P〈0.001）. Conclusion The level changes of hs-CRP and BNP is significant to the prognosis in patients with ACS undergone PCI.

关 键 词：脑钠肽 超敏C反应蛋白 主要心脏不良事件 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]