丹红注射液治疗老年早期糖尿病肾病的疗效及血清趋化素的变化  

Efficacy and Serum Chemerin Change in Treatment of Early Geriatric Diabetic Nephropathy with Danhong Injection

作　　者：王兴洲[1] 张红[1] 章向成[1] 吕述军[1] 高鹏霞[1] 

机构地区：[1]南京医科大学附属淮安第一医院内分泌科,江苏淮安223300

出　　处：《辽宁中医杂志》2015年第12期2337-2339,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81200595/81400807);江苏省卫计委科研项目(H201253);淮安市科技支撑计划社会发展项目(HASZ2013031)

摘　　要：目的:探讨丹红注射液治疗老年早期糖尿病肾病(diabetic nephropathy,DN)的临床疗效及血清趋化素(chemerin)水平变化。方法:60例老年2型糖尿病(type 2 diabetes mellitus,T2DM)并发早期DN患者随机分为治疗组(30例)和对照组(30例),均使用胰岛素常规控制血糖,治疗组加丹红注射液20 m L/d,疗程2周。检测治疗前后尿微量白蛋白排泄率(urinary albumin excretion rates,UAER)、血清chemerin、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)以及血糖、血脂变化。结果:两组UAER治疗后均较治疗前下降(P<0.05),治疗组优于对照组(P<0.05)。治疗组治疗后血清chemerin、TNF-α、hs-CRP均较治疗前降低(P<0.05),对照组变化无统计学意义(P>0.05)。两组治疗前后血糖、血脂变化无统计学意义(P>0.05)。结论:丹红注射液能在胰岛素常规降糖治疗基础上通过减轻炎症、减少UAER,对早期DN起到保护作用,chemerin可能在DN病理机制中发挥作用。Objective： To investigate the clinical efficacy and serum chemerin change in treatment of early geriatric diabetic nephropathy（ DN） with Danhong Injection. Methods： Sixty geriatric type 2 diabetes mellitus（ T2DM） patients with early DN were divided into treatment and control groups randomly. Both groups received routine glucose- lowering therapy with insulin and treatment group was given Danhong Injection（ 20 m L / d） for two weeks. Urinary albumin excretion rates（ UAER）,serum chemerin,tumor necrosis factor- α（ TNF- α）,high- sensitivity C- reactive protein（ hs- CRP）,blood glucose and lipids concentrations were measured before and after therapy. Results： UAER decreased after therapy in both groups（ P〈0. 05） and better results were obtained in the treatment group than those in the control group（ P〈0. 05）. In the treatment group,decreased levels of chemerin,TNF- α and hs- CRP after treatment were observed and compared with those before treatment（ P〈0. 05）. Their changes were not statistically significant in the control group（ P〉0. 05）. No statistical significances were found in the levels of blood glucose and lipids in both groups before and after treatment（ P〉0. 05）. Conclusion： Danhong Injection could alleviate inflammation and UAER on the basis of routine glucose- lowering therapy with insulin and protect early DN. Chemerin may play a role in the pathophysiology of DN.

关 键 词：2型糖尿病 老年早期糖尿病肾病 丹红注射液 疗效 CHEMERIN 

分 类 号：R587.2[医药卫生—内分泌]