血清1,25-二羟维生素D_3水平与儿童支气管哮喘的相关性研究  

Correlation between serum 25-hydroxy vitamin D_3 concentration level and children with bronchial asthma

作　　者：袁春雷[1] 官燕飞[1] 叶贵诚[1] 彭建明[1] 陈健锋[1] 王冬娥[1] 

机构地区：[1]中山市博爱医院检验科,广东中山528420

出　　处：《国际检验医学杂志》2015年第24期3535-3536,3540,共3页International Journal of Laboratory Medicine

基　　金：中山市科技计划项目(2014A1FC049)

摘　　要：目的探讨儿童血清1,25-二羟维生素D_3[1,25(OH)_2D_3]水平与支气管哮喘的相关性及其在哮喘患者中的水平变化。方法收集2012年1月至2014年12月中山市博爱医院儿科222例哮喘患儿与同期223例健康体检儿童,化学发光法检测其血清维生素D水平并评价其与儿童哮喘的相关性。结果相比健康体检儿童(93.39±27.15)nmol/L,哮喘患儿的血清维生素D水平明显较低为(86.30±27.70)nmol/L;在同一组内,不同年龄儿童的血清维生素D水平有显著性差异,不同性别之间则没有显著性差异。结论儿童的血清维生素D水平与其性别无关,随着年龄的增长而递减,哮喘组显著低于健康组,提示维生素D缺乏是哮喘发作的重要原因之一。Objective To investigate the relationship between serum 1,25-hydroxy vitamin D_3 concentration level and children with bronchial asthma.Methods 222 children with bronchial asthma treated in paediatrics of Zhongshan Boai hospital from 2012 Jan 2014Dec were chosen as asthma group（A）,while 223 cases of healthy children were selected as control group（C）.Electrochemical luminescence method was used to detect the serum level,and its effect on asthma was disscussed.Results The concentration of serum 1,25-hydroxy vitamin D_3 of asthma group（86.30±27.70nmol/L）was low than the control group（93.39±27.15nmol/）L.Serum levels of asthma group in different age groups（A1,A2 and A3）were 106.87±28.28nmol/L,88.98±20.65nmol/L,68.38±19.23nmol/L respectively,While those of control groups were（110.00±22.30）nmol/L,（87.36±24.42）nmol/L,（21.23±16.42）nmol/L respectively.Male and female serum level in asthma group were（88.26±27.73）nmol/L and（81.94±26.91）nmol/L respectively.While those of control group were（91.91±26.57）nmol/L and（85.69±28.04）nmol/L respectively.Conclusion There is significant correlation between serum 1,25-hydroxy vitamin D_3 level and children with bronchial asthma.,yet no correlation between serum level and gender.1,25-hydroxy vitamin D_3 duficiency is one of the risk factors of children asthma.

关 键 词：1 25-二羟维生素D_3 哮喘 儿童 

分 类 号：R725.6[医药卫生—儿科] R446.1[医药卫生—临床医学]