附子对急性心力衰竭大鼠血流动力学影响及其机制研究  

Effect of Aconiti Lateralis Radix Preparata on hemodynamics of rats with acute heart failure and its mechanism

作　　者：卢志强[1] 张艳军[1] 庄朋伟[1] 张金保[1] 周会芳[1] 陈卓[1] 孙萌[1] 徐利满 

机构地区：[1]天津中医药大学天津市中药药理重点实验室,天津300193

出　　处：《中草药》2015年第21期3223-3234,共12页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展规划("973"计划)项目(2011CB505300;2011CB505302)

摘　　要：目的复制急性心力衰竭模型,基于α、β肾上腺素能受体探讨附子抗急性心力衰竭药效作用及相关机制。方法采用iv大剂量戊巴比妥钠的方法复制大鼠急性心衰模型,分别设附子高、低剂量组及附子与α、β肾上腺素受体阻断药合用组,动态监测模型大鼠左室收缩压(LVSP)、心率(HR)、左室内压上升/下降最大速率(±dp/dtmax)等血流动力学相关指标,评价附子对急性心衰大鼠心功能的影响。结果与模型组相比,附子具有显著升高血压、加快HR及加强心肌收缩力的作用(P<0.05、0.01),且表现出一定程度的量-效、时-效关系。与附子给药组相比,α、β受体阻断药均能显著拮抗附子升压作用,β受体阻断药能显著拮抗附子加快HR作用(P<0.05、0.01)。结论附子对急性心衰大鼠具有明显的强心作用,其部分机制与激动α、β肾上腺素能受体有关。Objective To observe the effects of Aconiti Lateralis and Radix Preparata（ALRP） on hemodynamic indexes of rats with acute heart failure（AHF） and to study its possible mechanism of α and β adrenergic receptor-related action. Methods The AHF model in Wistar rats was induced by injecting large doses of pentobarbital. Rats were received high and low doses of ALRP as well as α and β adrenergic receptor blockers to observe the effect on hemodynamics（LVSP, HR, and ±dp/dtmax） in rats. Results ALRP could significantly increase blood pressure, heart rate, and myocardial contractility compared with the control group（P 〈 0.05, 0.01）, and it also exhibited a certain degree of volume-efficiency and time-effect relationship. The pressor effect of ALRP could be significantly reduced by α and β adrenergic receptor blockers. Moreover the increasing heart rate effect of ALRP could be significantly reduced by β adrenergic receptor blocker（P 〈 0.05, 0.01）. Conclusion ALRP can significantly enhance the cardiac function in rats with AHF and the possible mechanism of this effect is associated with α and β adrenergic receptors.

关 键 词：附子 急性心力衰竭 肾上腺素能受体 强心作用 血流动力学 

分 类 号：R285.5[医药卫生—中药学]