α-细辛脑纳米粒离子敏感型鼻用原位凝胶的制备及体外释药性能  

Preparation ofα-Asarone nanoparticle ion-sensitive in situ nasal gel and its drug releasing performance in vitro

作　　者：臧巧真 唐涛[1] 龙凯花 王春柳[2] 辛永洁[2] 李彤晖[2] 益慧慧 李晔[2] 

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西省中医药研究院,陕西西安710003 [3]西北大学生命科学学院,陕西西安710069

出　　处：《中国医院药学杂志》2015年第23期2115-2118,共4页Chinese Journal of Hospital Pharmacy

基　　金：陕西省重点科技创新团队计划项目(编号:2012KCT-18)

摘　　要：目的:制备α-细辛脑纳米粒离子敏感型鼻用原位凝胶并考察其体外释放行为。方法:采用去乙酰结冷胶(DGG)为凝胶基质,以凝胶黏度,形成凝胶的能力及持水力为考察指标筛选去乙酰结冷胶的用量;采用纳米沉淀法制备α-细辛脑纳米粒,与凝胶基质混合后制得α-细辛脑纳米粒离子敏感型原位凝胶;以人工模拟鼻液为释放介质、考察制剂的体外释放特性。结果:确定0.5%的结冷胶作为α-细辛脑纳米粒离子敏感型原位凝胶的基质,在非生理状态为自由流动的液体,生理状态下能够发生相变形成凝胶。体外释放结果表明α-细辛脑纳米粒离子敏感型鼻用原位凝胶具有较好的缓释作用。结论:α-细辛脑纳米粒离子敏感型原位凝胶的胶凝效果良好,缓释作用明显且制备工艺简单可行。OBJECTIVE To prepare ion-sensitive in situ nasal gel containingα-Asarone nanoparticles and study its in vitro release behavior.METHODS Gellan gum was used as gel matrix,and viscosity of in situ gel,ability to form gel and holding capacity were adopted as targets to select quantity of gellan gum.α-Asarone nanoparticles were prepared with nanoprecipitation method,and then were mixed with gellan gum to prepare nanoparticle ion-sensitive in situ gel.Simulated nasal fluid was applied as release medium to study in vitro release characteristics ofα-Asarone nanoparticle ion-sensitive in situ gel.RESULTS0.5% gellan gum was suitable toα-Asarone nanoparticles ion-sensitive in situ gel.It was semi-transparent fluid at non-physiological state,turned into semi-solid at physiological status.The in vitro study indicated thatα-Asarone nanoparticle ion-sensitive in situ gel possessed superior sustained-release effects.CONCLUSION α-Asarone nanoparticle ion-sensitive in situ gel has good gelatinizing effects,obvious sustaining effects,the preparing technique is simple and feasible.

关 键 词：Α-细辛脑 纳米粒 离子敏感原位凝胶 体外释放 

分 类 号：R943[医药卫生—药剂学]