非小细胞肺癌分子分型与信号调控网络  

Onco-driver genes and their signaling networks in non-small cell lung cancer

作　　者：安世民[1,2] 丁旭苹 朱亮[1,2] 

机构地区：[1]上海交通大学医学院药理学教研室,上海200025 [2]上海交通大学医学院转化医学协同创新中心,上海200025

出　　处：《中国新药杂志》2015年第24期2797-2802,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81173084);上海市自然科学基金(12ZR1415700);上海市教委科研创新基金(14YZ032)

摘　　要：近年来随着环境污染、生活方式等的变化,非小细胞肺癌(non-small cell lung cancer,NSCLC)的发病率和死亡率不断上升。传统以手术结合放化疗的治疗方式对NSCLC的治疗效果不甚理想,寻找有效的药物靶点成为肺癌治疗急需解决的问题。随着测序技术、FISH等检测方法的进步,对肺癌患者的癌症驱动基因进行病理诊断及推动个体化治疗变得可行。本文对NSCLC的常见癌基因分型和信号调控网络以及相应的药物靶点进行综述。The occurrence and death rate of non-small cell lung cancer（ NSCLC） are increasing in recent years as environmental pollution and people life style change. Therapy effect of conventional surgical plus radiochemotherapy is not satisfying,thus searching for ideal drug targets is critical for NSCLC treatment. Development of pathology technology like gene sequencing and FISH etc. rendered detection of onco-driver genes possible,and promoted the personalized treatment strategies. This review summarized the common onco-driver genes,signaling pathways and corresponding drug targets in NSCLC.

关 键 词：非小细胞肺癌 癌基因分型 信号网络 

分 类 号：R974[医药卫生—药品]