骨代谢标志物在宁波地区绝经后女性骨质疏松症患者中的临床应用  

Clinical application of bone metabolic markers in postmenopausal women with osteoporosis in Ningbo area

作　　者：王福斌[1] 陈剑明[1] 吴坚敏[1] 李淑敏[1] 罗晶[1] 

机构地区：[1]宁波市第六医院骨质疏松诊疗中心,浙江宁波315040

出　　处：《中国骨质疏松杂志》2015年第12期1484-1486,共3页Chinese Journal of Osteoporosis

基　　金：宁波市社发项目(2014C50047)

摘　　要：目的研究骨代谢标志物在宁波地区绝经后中老年女性骨质疏松症患者诊疗中的作用。方法随机选择绝经后的中老年女性受试者264例,年龄均大于50岁,根据骨密度结果将264例检测对象根据骨密度大小分为骨量正常组82例,骨量减少组90例,骨质疏松组92例,同时采用电化学发光免疫分析方法测定受检对象血清中β-CTX、PINP、25-OHD3水平,并进行对比分析。结果骨质疏松组:β-CTX水平与正常对照组、骨量减少组比较差异有统计学意义(P<0.05);PINP、25-0HD3水平在3组间差异无统计学意义(P>0.05)。结论骨质疏松症患者血清骨代谢标志物水平与骨质疏松存在密切的相关性;β-CTX是骨质疏松症诊断和疗效评估的理想指标;PINP、25-0HD3是骨质疏松症诊断和治疗的参考指标。Objective To analyzetheroleof bonemetabolic markers in postmenopausal women with osteoporosis in Ningbo area. Methods Two hundred and sixty-four postmenopausal women,aged over 50 years old,wererandomly selected. According to theresults of thebonemineral density,the264 cases weredivided into threegroups： 82 cases in normal bonemass group,90 cases in bonemass reduction group,and 92 cases in osteoporosis group. Serum β-CTX,PINP,and 25-（ OH） D3 levels weredetermined using electrochemiluminescenceimmunoassay method. Theresults werecomparatively analyzed. Results β-CTX level was statistically different among thethreegroups（ P〈0. 05）. PINP and 25-OHD3 levels werenot different among thethreegroups（ P〉0. 05）. Conclusion Thereis a closecorrelation between serum bonemetabolic markers and osteoporosis in postmenopausal women. β-CTX is an ideal evaluation index for diagnosis and curativeeffect of osteoporosis. PINP and 25-OHD3 arereferenceindex in diagnosis and treatment of osteoporosis.

关 键 词：骨质疏松症 骨密度 骨代谢标志物 β-胶原特殊序列 血清I型原胶原N-端前肽 25-羟基维生素D3 

分 类 号：R446.6[医药卫生—诊断学]