金天格胶囊在预防绝经后女性骨质疏松性骨折中的作用  

The effect of Jintiange capsule on the prevention of postmenopausal osteoporotic fractures

作　　者：甘强[1] 谭祖建[1] 周明全[1] 胡维[1] 

机构地区：[1]重庆市中山医院骨科中心,重庆400013

出　　处：《中国骨质疏松杂志》2015年第12期1498-1500,1516,共4页Chinese Journal of Osteoporosis

基　　金：重庆市卫生计生委医学科研项目(20142087)

摘　　要：目的观察金天格胶囊在治疗绝经后女性骨质疏松的疗效,判断其预防骨折发生的概率。方法选取绝经后骨质疏松女性238名,随机分为4组,第1组:金天格59例,第2组:钙尔奇D+金天格58例,第3组:钙尔奇D+金天格+阿仑膦酸钠63例,第4组:钙尔奇D+阿仑膦酸钠58例;服药剂量:金天格1.2mg,tid;钙尔奇D 600mg qd;福善美70mg qw。分别在服药前、服药后3、6个月检测骨密度(bone mineral densities,BMD)、血清1型原胶原N-端前肽(PINP)和1型胶原交联C-末端肽(CTX)。结果各组骨密度无明显变化(P>0.05);服药3个月,4组的PINP分别下降了18.2%、22.3%、62.3%、55.8%,CTX分别下降了24.3%、29.7%、68.7%、57.8%;服药6个月,4组的PINP分别下降了19.4%、23.6%、63.5%、62%,CTX分别下降了28.1%、28.3%、69.9%、64.5%。结论金天格胶囊可以明显降低骨转化指标,能有效辅助治疗骨质疏松和预防骨折的发生。Objective To observetheefficacy of Jintiangecapsuleon thetreatment of osteoporosis and to judgetheprobability of osteoporotic fractureprevention in postmenopausal women. Methods Two hundred and thirty-eight postmenopausal women with osteoporosis wereselected and randomly divided into 4 groups,Group one（ Jintiangecapsulegroup,n = 59）,Group two（ calcium and Jintiangecapsulegroup,n = 58）,Group three（ calcium and Jintiangecapsuleand bisphosphonategroup,n = 63）,and Group four（ calcium and bisphosphonategroup,n = 58）. Thedosageof thedrugs was 1. 2mg of Jintiangecapsule,tid,600 mg of calcium,qd,and 70 mg of bisphosphonates,qw. Bonemineral densities（ BMD）,serum procollagen typeI amino-terminal propeptide（ PINP）,and serum C-terminal cross-linked telopeptides of typeI collagen（ CTX） weredetected beforeand after 3months and 6 months of thetreatment,respectively. Results BMD was not obviously changed in each group（ P〉0. 05）. After 3months of treatment,PINP decreased by 18. 2%,22. 3%,62. 3%,and 55. 8%,respectively,in each group,and CTX decreased by 24. 3%,29. 7%,68. 7%,and 57. 8%,respectively,in each group. After 6 months of treatment,PINP decreased by 19. 4%,23. 6%,63. 5%,and 62%,respectively,in each group,and CTX decreased by 28. 1%,28. 3%,69. 9%, and 64. 5%,respectively,in each group. Conclusion Jintiangecapsulecan obviously decreaseboneturnover markers,and can effectively adjuvant thetreatment of osteoporosis and prevent osteoporotic fracture.

关 键 词：骨质疏松 金天格胶囊 骨转化指标 骨密度 

分 类 号：R977.9[医药卫生—药品] R683[医药卫生—药学]