右美托咪定对颌面外科手术患者全身麻醉恢复和尿量的影响  

Effects of Dexmedetomidine Intravenous Infusion on the Recovery Process and Urinary Production of Patients Undergoing Dentofacial Surgery

作　　者：张建友[1] 王林[1] 孙建宏[1] 张荦[1] 

机构地区：[1]扬州市第一人民医院麻醉科,225000

出　　处：《医学研究杂志》2015年第12期148-151,共4页Journal of Medical Research

摘　　要：目的观察右美托咪定对颌面外科手术患者全麻恢复和尿量的影响。方法择期颌面外科整形患者50例（ASAⅠ级）,随机分为生理盐水对照组（control）以及DEX 0.4、0.8、1.0μg/kg 4组（D1～D3组）。术中监测尿量和术后苏醒时间、拔管时间、镇静镇痛评分、雷米芬太尼消耗量和失血量,比较各组间差异。结果各观察组较对照组拔管期的平均动脉压（MAP）和心率（HR）更稳定,术中雷米芬太尼消耗减少,而失血量差异无统计学意义（P〉0.05）。观察组各剂量组均在输注后2h尿量增加达峰值。与对照组相比,D3和D2组累积尿量明显增多（P〈0.05）,而对照组与D1相比差异无统计学意义（P〉0.05）。结论右美托咪定能显著减轻全身麻醉苏醒期血流动力学指标,减少术中阿片类药物消耗,增加尿量,但大剂量[1μg/（kg·h）]明显延长全麻恢复时间。Objective To study the effects of dexmedetomidine on urinary production and recovery of general anesthesia in dentofacial surgery. Methods Fifty ASAⅠpatients, scheduled for Oral and Maxillofacial Surgery were randomly assigned to 4 groups （n=12）：（Group Control）：control group;（Group D1-D3）：DEX 0.4,0.8,1.0μg/kg groups. The urinary volume, times of recovery and extubation, level of pain and consciousness were recorded and evaluated during the anesthesia. Results Compared with group P, consumption of remifentanil was significantly decreased （P〈0.05） and more steady MAP and HR were found in DEX group. No significant difference was found between groups in blood loss （P〉0.05）. There was no significant difference between groups D3 and D4 （P〉0.05）. Urinary production in group D2 and D3 increased significantly （P〈0.05）. Conclusion DEX reduced the consumption of remifentanil, improved the comfort of extubation and elevated the urinary production.

关 键 词：右美托咪定 恢复 尿量 颌面外科 

分 类 号：R614[医药卫生—麻醉学]