早期2型糖尿病人群身体成份对骨密度的影响  

Effect of body composition on bone mineral density in early stage of type 2 diabetes

作　　者：刘畅[1] 张巧[1] 时立新[1] 张淼[1] 彭年春[1] 

机构地区：[1]贵阳医学院附属医院内分泌代谢病科,贵阳550004

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2015年第4期322-328,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的探讨身体成份对中老年2型糖尿病患者骨密度（bone mineral density,BMD）的影响。方法选取为2012年内分泌科住院2型糖尿病患者224例（男性115例、女性109例）,年龄40~75岁、病程不超过5年、未使用胰岛素治疗且无明显糖尿病并发症。研究对象均进行体检,检测糖化血红蛋白（glycosylated hemoglobin,Hb A1c,Simens,DCA Wantege）、BMD及身体成份（美国Hologic公司,ASY-00409双能X线骨密度仪）。结果瘦组织与股骨颈、髋部、脊柱BMD呈正相关（相关系数r分别为0.61、0.64、0.60,P值均小于0.05）;校正年龄、Hb A1c、体质量指数（body mass index,BMI）后,体脂含量与女性脊柱（L1-4）BMD呈正相关（相关系数r=0.24,P〈0.05）,与男性BMD无明显相关性;腹型肥胖（Android）与股骨颈、髋部、脊柱（L1-4）BMD呈正相关（r分别为0.27、0.32、0.26,P均〈0.05）。结论瘦组织对BMD产生有利影响,体脂含量对绝经女性产生有利影响,而对男性BMD则无保护作用。Objective To explore the influence of body composition on bone mineral density（ BMD） among middle-aged and elderly diabetics. Methods Subjects for this cross-sectional analysis were men（ n = 115） and women（ n = 109） aged 40- 75 years（ 59 ± 9） with uncomplicated,course of disease less than 5 years,noninsulin-required type 2 diabetes. Blood pressure,height,weight,waist circumference,body mass index（ BMI） was measured. Glycosylated hemoglobin（ Hb A1c） were tested（ Simens,DCA Wantege）. BMD and body composition were measured（ dual energy X-ray absorptiometry Hologic, ASY-00409）. Results Lean mass positively correlated with BMD at femoral neck,hip and lumbar spine L1-4;（ r = 0. 61,0. 64,0. 60,P〈0. 05）. After adjusted with BMI,Hb A1 c and age,fat mass positively correlated with BMD at lumbar spine L1-4in women（ r = 0. 24,P〈0. 05）,however,no obvious correlation with BMD in men. Android positively correlated with BMD at femoral neck,hip and lumbar spine（ r = 0. 27,0. 32,0. 26,P〈0. 05）. Conclusion Lean mass has positive effect on BMD. Fat mass has positive effect on BMD in women,but has no effect on BMD in men.

关 键 词：身体成份 骨密度 中老年 2型糖尿病 

分 类 号：R445[医药卫生—影像医学与核医学]