平肝通脉汤治疗不稳定性心绞痛合并原发性高血压疗效及安全性评价  

Observation of effect and safety of Pinggan- tongmai decoction on the treatment of unstable angina combined with hypertension

作　　者：周凤鱼 宋国斌[2] 王仁平[1] 马文晶[1] 陈鲜茹 王丽欣[1] 

机构地区：[1]石家庄长城中西医结合医院心内科,河北石家庄050035 [2]河北省石家庄市第一医院老年科,河北石家庄050011

出　　处：《河北中医》2015年第12期1776-1779,1804,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2014年度中医药类科研计划课题(编号:2014093)

摘　　要：目的观察平肝通脉汤治疗不稳定性心绞痛合并高血压的疗效,并评价其安全性。方法将120例不稳定性心绞痛合并原发性高血压患者随机分为2组,对照组60例予常规西药治疗,治疗组60例在对照组西药方案基础上,予平肝通脉汤辅助治疗。4周后比较治疗前后血压、心电图及中医证候改变情况,并统计不良反应发生情况。结果治疗组治疗后心绞痛发作次数及发作持续时间、收缩压及舒张压均降低(P<0.05),心电图ST段及T波倒置均明显改善(P<0.05),且改善情况均优于对照组(P<0.05)。治疗组心绞痛改善总有效率88.3%,优于对照组(60.0%,P<0.05)。治疗组心电图改善总有效率86.7%,优于对照组(50.0%,P<0.05)。治疗组降压疗效总有效率88.3%,优于对照组(68.3%,P<0.05)。治疗组中医证候疗效总有效率90.0%,优于对照组(68.3%,P<0.05)。治疗组不良反应发生率8.33%,对照组13.3%,2组比较差异无统计学意义(P>0.05)。结论平肝通脉法用于不稳定性心绞痛合并高血压的治疗,能够在不影响安全性的前提下提高心绞痛及原发性高血压的治疗效果,值得在临床上推广研究。Objective To observe the effect and safety of Pinggan -tongmai decoction on the treatment of unstable angina combined with hypertension. Methods 120 unstable angina patients combined with hypertension were randomly divided into two groups. 60 patients in control group were treated by routine western medicine. 60 patients in treatment group were treated by Pinggan - tongmai decoction on the basis of control group treatment. The course was four weeks in two groups. The changes of blood pressure, electrocardiogram （ECG） and traditional Chinese medicine （TCM） syndrome before and after treatment were compared, and the adverse reaction was observed in two groups. Results The frequency and duration of angina attacks, systolic pressure and diastolic pressure after treatment in treatment group were decreased （P 〈 0.05）. The ST segment and T wave inversion on ECG after treatment in treatment group were obviously improved （P 〈 0.05）, and the improvement in treatment group was superior to those in control group （P 〈 0.05 ）. The total improvement rate of angina in treatment group （88.3 % ） was superior to that in control group （60.0% ,P 〈0.05 ）. The total improvement rate of ECG in treatment group （86.7%） was superior to that in control group （ 50.0%, P 〈 0.05 ）. The total effective rate of antihypertensive in treatment group （88.3%） was superior to that in control group （68.3% , P 〈 0.05 ）. The total effective rate of TCM syndrome in treatment group （90.0%） was superior to that in control group （68.3% ,P 〈0.05）. The adverse effect rate in treatment and control group was 8.33% and 13.3% respectively, there was no statistical difference （P 〉 0.05 ）. Conclusion Pinggan - tongmai decoction can improve the therapeutic effect on the treatment of unstable angina corn-bined with hypertension while not reduce the security, worthy of further study and development.

关 键 词：心绞痛 不稳定型 高血压 中药疗法 治疗结果 

分 类 号：R541.420.58[医药卫生—心血管疾病] R544.105.8[医药卫生—内科学]