MRI弥散加权成像对宫颈癌新辅助化疗评估的应用价值  

Value of diffusion weighted magnetic resonance imaging in the monitoring of neoadjuvant chemotherapy efficacy for uterine cervical cancer

作　　者：巴志昌[1] 王欣欣[1] 崔万辉 国飞[1] 张修石[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院放射诊断科,哈尔滨150081 [2]哈尔滨骨伤科医院

出　　处：《实用肿瘤学杂志》2015年第6期518-522,共5页Practical Oncology Journal

摘　　要：目的探讨磁共振扩散加权成像（DWD对宫颈癌新辅助化疗疗效的评估价值。方法收集我院经病理证实的3l例宫颈癌患者，均于新辅助化疗前后行常规MRI及DWI检查，评估化疗前后肿瘤的DWI图像及其ADC值的变化。结果治疗前肿瘤最大横径（37．10±11．23）与治疗前ADC值（0．83±0．12）之间的相关关系没有统计学意义（r=-0．175，P=0．348）；治疗后肿瘤最大横径（24．03±5．65）与治疗后ADC值（1．10±0．16）之间的相关性没有统计学意义（r=-0．208，P=0．262）；治疗前后肿瘤横径缩小程度与ADC增加之间相关性具有统计学意义（r=0．419，P=0．019）；化疗有效组20例，无效组11例，有效组治疗后ADC值（0．95±0．13）较治疗前ADC值（0．80±0．12）明显升高，其变化具有统计学意义（P〈0．05），而无效组治疗前ADC值（0．88±0．10）与治疗后ADC值（0．95±0．13）差异无统计学意义（P〉0．05）。结论DWI序列有助于早期预测和评估宫颈癌新辅助化疗疗效。Objective To analyze the value of diffusion weighted imaging（DWI） in assessing the effect of neoadjuvant chemotherapy of uterine cervix cancer. Methods Thirty one patients with LACC confirmed by pa- thology received conventional magnetic resonance imaging and DWI before and after neoadjuvant chemotherapy. The variation of DWI image and ADC was evaluated before and after chemotherapy. Results The correlation be- tween maximum diameter of the tumor before treatment （37.10 ± 11.23 ）and pretreatment ADC value （0.83 ± 0.12） was not statistically significant（ correlation coefficient r = - 0. 1746, P = 0. 3475 ） ; the correlation between the maximum diameter of the tumor（24.03 ± 5.65）and ADC value（ 1.10 ± 0.16）after treatment was not statisti- cally significant（correlation coefficient r = -0. 2077 ,P =0 2621. ） ;the degree of tumor size before and after the treatment was correlated with the degree of ADC increase（ P 〈 0.05 ） ;Effective chemotherapy group of 20 cases, invalid group of 11 cases, ADC value of effective treatment group after treatment （0.95 ± 0. 13 ）was significantly higher than ADC value before chemotherapy （0.80 ± 0.12）, the change was statistically significant （ P 〈 0.05 ）, while the difference between former ADC value（0.88±0. 10） and ADC value after treatment（0.95 ±0.13）of ineffective group therapy was not statistically significant（ P 〉 0.05 ）. Conclusion DWI sequence may be useful for early prediction and evaluation of curative effect to neoadjuvant chemotherapy for uterine cervical cancer.

关 键 词：磁共振 弥散加权成像 宫颈癌 新辅助化疗 

分 类 号：R445.2[医药卫生—影像医学与核医学]