血管内皮生长因子和结缔组织生长因子在增生型糖尿病视网膜病变中的研究进展  

Recent advances of researches on the roles of vascular endothelial growth factor and connective tissue growth factor in proliferative diabetic retinopathy

作　　者：李若琳[1] 陈楠[2] 

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院山东省眼科研究所,250022 [2]山东省眼科研究所青岛眼科医院,青岛266071

出　　处：《临床眼科杂志》2015年第6期573-576,共4页Journal of Clinical Ophthalmology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(编号:BS2010YY064)

摘　　要：增生型糖尿病视网膜病变(PDR)是糖尿病视网膜病变(DR)的严重阶段,其主要的病理改变是新生血管形成和纤维组织增生,由此引起的反复玻璃体积血和牵拉性视网膜脱离等并发症严重影响视力。国内外的研究已表明PDR的发生发展受多种细胞因子的影响与调控,血管内皮生长因子(VEGF)和结缔组织生长因子(CTGF)是与PDR关系密切的其中两个因子。VEGF除具有促进新生血管生成之外,还具有神经细胞营养保护作用。CTGF在PDR形成过程中具有促进新生血管形成及纤维化的双重作用,并且可能参与增生膜的形成。现就这两种因子在PDR中的研究进展作一综述。Proliferative diabetic retinopathy（ PDR） is the later stage of diabetic retinopathy. Main pathological changes,including neovascularization and fibrosis,can lead to recurrent vitreous hemorrhage,tractional retinal detachment and other complications that seriously affect vision. Many researches have shown that the development of PDR is regulated by a variety of cytokines. Among them,vascular endothelial growth factors（ VEGFs） and connective tissue growth factors（ CTGFs） are the most closely related cytokines. VEGFs not only promote angiogenesis,but also have a protective effect on nerve cell nutrition. CTGFs also have dual roles in angiogenesis and fibrosis and may be involved in formation of the hypertrophic film. The current research progress of these two factors in PDR is reviewed in this article.

关 键 词：增生型糖尿病视网膜病变 血管内皮生长因子 结缔组织生长因子 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]