可控尺寸的壳聚糖微球制备  

Preparation of chitosan microsphere with controllable size

作　　者：张晴[1,2] 张玉芳[1] 任玲玲[2] 

机构地区：[1]北京服装学院,北京100029 [2]中国计量科学研究院,北京100013

出　　处：《化工新型材料》2015年第12期76-78,共3页New Chemical Materials

基　　金：科技部国家支撑项目(2011BAK15B04);北京服装学院2014年研究生科研创新项目(X2014-082)

摘　　要：以壳聚糖为单体,戊二醛为交联剂,采用反相悬浮-化学交联法制备了不同条件下的壳聚糖微球。实验结果表明:随着冰乙酸浓度、壳聚糖浓度和乳化剂含量的增大,微球粒径先减小后增大;而随着搅拌速度的增大,微球粒径呈逐渐减小的趋势,控制成球的反应条件可以制备出不同粒径的壳聚糖微球,并在此基础上探讨了微球的生长机理。Chitosan microspheres were prepared with inverse suspension-chemical crosslinking method using chitosan as the monomer,glutaraldehyde as crosslinker.The experimental results showed that with the increase of acetate concentration,chitosan concentration and emulsifier content,particle size decreased first and then increased.And with the increase of stirring speed,microspheres particle size were decreased gradually.Controled the reaction conditions can prepared chitosan microspheres of different size,and on this basis to explore the growth mechanism of microspheres.

关 键 词：壳聚糖微球 反相乳化交联 粒径 

分 类 号：O636.1[理学—高分子化学]