水热法制备掺锶羟基磷灰石及其性能研究  

Hydrothermal preparation and property of strontium substituted hydroxyapatite

作　　者：赵俊锋[1] 查佳晨 韦波[1] 王郁洁[1] 陆洪彬[2] 钱钰[1] 陈建华[1,3] 

机构地区：[1]常熟理工学院化学与材料工程学院,常熟215500 [2]南京大学南通材料工程技术研究院,南通226019 [3]常熟理工学院江苏省新型功能材料重点建设实验室,常熟215500

出　　处：《化工新型材料》2015年第12期149-151,共3页New Chemical Materials

基　　金：江苏省新型功能材料重点实验室开放基金项目(10KFJJ006);江苏省自然科学基金(BK2012210)

摘　　要：采用水热法制备了不同比例Sr掺杂羟基磷灰石(HA)纳米粉体,在不同温度条件下检测了不同比例掺SrHA的热稳定性,结果表明纯HA在900℃高温下基本不分解,随着Sr的掺入,Sr-HA的热稳定性下降,且含Sr量越多,热稳定性越差;同时,以牛血清蛋白(BSA)为药物模型,与纯HA相比,Sr的掺入可以提高药物的释放速度,具有良好的药物缓释效果。Several stoichiometric strontium substituted hydroxyapatite powders were synthesized by the hydrothermal method.The thermal stabilities,including phase structure,chemical composition were investigated at different temperature.Results showed that no change happened to phase component of pure HA at 900℃.However,the thermal stability declined with the Sr incorporation into hydroxyapatite,and more obvious with increasing of Sr concentration.Bovine serum albumin（BSA）was chosen to test the medicine delayed-release performance of Sr-HA.Results showed that the release rate was improved with the Sr incorporation into hydroxyapatite,and had obvious effect of delayed-release.

关 键 词：锶羟基磷灰石 热稳定性 牛血清蛋白 缓释 

分 类 号：O614.231[理学—无机化学]