白银地区5岁以下住院儿童RSV感染流行病学分析  

Epidemiological analysis of respiratory syncytial virus in pediatric patients under 5 years in hospital with pneumonia in Baiyin district.

作　　者：乔瑞娟[1] 汪鹏[1] 康倩[1] 王旭霞[1] 张入学[2] 陈建华[1] 倪丰安[2] 冯双成[3] 李普[4] 于德山[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000 [2]白银市疾病预防控制中心 [3]白银市第一人民医院 [4]白银市第二人民医院

出　　处：《中华实验和临床病毒学杂志》2015年第6期510-514,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项（2012ZX1004208）;2015年甘肃省卫生行业科研计划项目（GSWSKY-2015-36）

摘　　要：目的了解甘肃省白银地区儿童中呼吸道合胞病毒（RSV）的病原学特点及流行特征，为甘肃省RSV疾病的诊断治疗及疫苗的应用等提供依据。方法选取白银市3家哨点医院，从2012年4月--2015年3月期间每月采集5岁以下肺炎住院儿童的深部吸痰标本共1400份，进行呼吸道病原谱的检测，其中RSV病毒使用双通道实时荧光PCR检测。结果5岁以下肺炎儿童RSV感染总体阳性率为33．00％；462例RSV阳性患儿中，247例为A亚型，215例为B亚型，在2012-2014年以RSVB为主，2014—2015年以RSVA为主；2岁以下年龄组较2岁以上儿童RSV阳性检出率高（P〈0．05），RSV感染的高峰季节在冬春季节12月至次年3月期间；A、B两个亚型交替流行。结论RSV病毒是白银市5岁以下儿童下呼吸道感染病例中病毒性病原的首位，每年冬春季节存在流行高峰。A、B两个亚型交替流行。Objective To study the epidemic characteristics of respiratory syncytial virus （RSV） in pediatric patients in Baiyin district in Gansu Province. Methods 1400 nasopharyngeal aspirates were collected from pediatric patients under 5 years in hospital with pneumonia from April 2012 to March 2015. The specimens were detected and sub-types for RSV using real-time PCR. Results Out of 1400 specimens, 462 （33.00%） were positive for RSV, subtypes of A and B accounted for 247 and 215. The majority of infected children was under 2 years old （ P 〈 0. 05 ）. The high peak season of RSV infection appeared in winter-spring from December to next March. The dominant subtype was alternated between A and B. Conclusions RSV infection rate was highest in children of 2 years old, the high peak seasons of RSV infection were in winter and spring, and the dominant subtype was alternated between A and B.

关 键 词：呼吸道合胞病毒 儿童 流行病学 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]