胰岛素治疗2型糖尿病患者对药物治疗依从性和糖尿病自我管理的随机对照实验  

Insulin therapy in patients with 2 type diabetes： Medication adherence and diabetes self-management of a randomized controlled trial

作　　者：牛小娟[1] 许瑞元[1] 郑艳宇[1] 侯红斌[1] 贾春晖[1] 罗晓红[1] 

机构地区：[1]兰州军区兰州总医院内分泌科,730050

出　　处：《中华内分泌代谢杂志》2015年第12期1031-1033,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81173620）

摘　　要：探讨胰岛素治疗的2型糖尿病患者血糖控制状况。用随机数字表法抽取年龄≥45岁且用胰岛素降血糖治疗后HbA1C≥8．0％的70例成年2型糖尿病患者，进行为期6个月的随访。将70例糖尿病患者用随机数字表法分为对照组和干预组，每组35例。干预组在常规降血糖的基础上为其建立一个个性化的药物治疗和健康教育计划。治疗计划主要是测定HbA1C的变化，其次包括糖尿病用药知识的掌握、对药物的依从性、胰岛素注射技术及家庭血糖的监测、糖尿病相关的生活质量监控情况。并于干预前后进行调查问卷评估。干预组患者的糖尿病用药知识的掌握、药物依从性、正确的胰岛素注射方法以及自我血糖监测技术均得到了显著提高，而对照组无明显变化。6个月后，干预组的HbA1C值较前显著降低（P〈0．01），而对照组无明显变化。To discuss blood glucose control in patients with type 2 diabetes undergoing insulin therapy. A randomized controlled trial was conducted in type 2 diabetics who were taking insulin and who had an HbAlc level I〉 8%, with a 6-month follow-up period. 70 diabetic patients were randomly and equally divided into control group who received standard care, and intervention group who received an individualized personalized medical treatment with health education. The main outcome measures were change of HbAlc, diabetes and medication knowledge, adherence to medications, family blood glucose monitoring, and insulin injection techniques. Questionnaire was used to evaluate the outcomes before and after the intervention. The medication and diabetes knowledge, medication adherence, the correct way for home blood glucose monitoring were significantly improved in intervention group, while remained unchanged in the control group. After 6 months, HbAlc values were significantly reduced in the intervention group while remained unchanged in the controls. The quality of life also significantly improved in the intervention group.

关 键 词：糖尿病 2型 药物治疗依从性 自我管理 门诊治疗 

分 类 号：R473.5[医药卫生—护理学]