益母草生物碱药理毒理学研究进展  

Research Progress on Pharmacology and Toxicology in Alkaloid of Leonurus

作　　者：赵红[1] 李世民[2] 窦立雯 尹利顺 孙晓倩[3] 李晓宇[2] 孙玲 孙蓉[2] 

机构地区：[1]中国人民解放军海军总医院,北京100048 [2]山东省中医药研究院,山东济南250014 [3]山东中医药大学,山东济南250355 [4]山东省药学科学院,山东济南250101

出　　处：《中国药物警戒》2015年第12期722-726,共5页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金项目(81450021);山东省自主创新和成果转化项目(2014ZZCX02104)

摘　　要：目的通过对益母草生物碱药理学和毒理学研究进展进行总结与分析,为合理用药提供文献依据。方法对国内外近20年来相关文献进行整理、归纳和分析。结果益母草生物碱具有调节子宫、止血、抗炎镇痛、利尿等药理作用,对顺产和剖腹产产后出血均有较好疗效。但是临床药品不良反应报道和肾毒性报道表明长期大量服用可引起肝、肾脏损害等毒副作用。结论益母草总生物碱所涉及中成药品种有胶囊和注射剂,注重药效研究过程中的毒副作用特点及毒靶机制研究,为益母草总生物碱临床不良反应的早期预警方案和科学应对措施提供数据支撑,为含益母草制剂的临床安全用药提供有益参考。Objective To provide references for rational use of drags by summarizing and analyzing the study of pharmacology and toxicology in alkaloid of Leonurus. Methods The literatures which were published in the last twenty years were sorted, concluded and analyzed. Results Alkaloid of Leonurus has regulation of uterus, hemostasis, anti-inflammation and analgesia, diuresis and other pharmacological effects, which has good effect on postpartum hemorrhage of eutocia and caesarean secion. However clinical ADR and renal toxicity report showed that long-term use can cause liver and kidney damage and other toxic side effects. Conclusion The total alkaloids from Leonums containing drugs involve capsules and injections. Paying attention to toxic side effects and target mechanism in the process of drug efficacy study will provide data supporting for early warning method of clinical adverse reactions and scientific measures and provide beneficial reference of clinical safe medication of Herba Leonuri preparation.

关 键 词：益母草生物碱 药理学 毒理学 

分 类 号：R965[医药卫生—药理学] R282[医药卫生—药学]