急性脑梗死患者血浆纤维蛋白原、脂蛋白相关磷脂酶A2水平与颈动脉粥样硬化斑块关系分析  

Relation between plasma fibrinogen, lipoprotein-associated phospholipase A2 levels and carotid atherosclerosis plaque in patients with acute cerebral infarction

作　　者：朱学芳[1] 张鹏[2] 金建龙[3] 钱沂[4] 

机构地区：[1]江苏省如皋市人民医院神经内科,226500 [2]江苏省如皋市人民医院神经外科,226500 [3]江苏省如皋市人民医院放射科,226500 [4]江苏省如皋市人民医院感染管理科,226500

出　　处：《临床内科杂志》2015年第12期811-813,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨急性脑梗死（ACI）患者血浆纤维蛋白原（FIB）、脂蛋白相关磷脂酶A2（Lp—PLA2）水平变化特点及与颈动脉粥样硬化斑块的关系。方法选取2011年6月-2014年10月我院诊治的急性脑梗死患者80例作为脑梗死组，并选取同期我院健康体检者80例为对照组，彩色多普勒超声检测颈总动脉粥样硬化斑块，全自动血凝仪检测FIB水平，酶联免疫吸附试验（ELISA）法检测Lp-PLA2水平，分析急性脑梗死患者FIB、Lp-PLA2水平变化特点及与颈动脉粥样硬化斑块Crouse积分之间关系。结果脑梗死组患者Lp—PLA2、FIB、超敏C反应蛋白（hs—CRP）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）的水平均明显高于对照组，高密度脂蛋白胆固醇（HDL—C）水平明显低于对照组（P〈0．05）；FIB、Lp-PLA2水平不稳定斑块组〉稳定斑块组〉无斑块组，3组间比较差异有统计学意义（P〈0．05）；急性脑梗死患者FIB、Lp-PLA2水平与Crouse积分呈正相关（r=0．514、r=0．813，P均〈0．05）。结论急性脑梗死患者FIB、Lp—PLA2水平与颈动脉粥样硬化程度相关。Objective To explore the relationship between fibrinogen（FIB） ,lipoprotein-associated phospholipase A2 （Lp-PLA2） levels and carotid atherosclerotic plaque in patients with acute cerebral in- farction （ACI）. Methods A total of 80 ACI patients from June 2011 to October 2014 in our hospital were selected as cerebral infarction group, and a total of 80 healthy people were selected as control group. The total carotid atherosclerotic plaque scores were texted by color Doppler ultrasound, FIB level were detected by automatic coagulation analyzer, Lp-PLA2 levels were detected by ELISA. The relationship between FIB, Lp-PLA2 levels and acute cerebral infarction size, carotid atherosclerotic plaque Crouse points in patients were analyzed. Results The Lp-PLA2, FIB, hs-CRP, TG, TC, LDL-C levels in infarction patients were significantly higher than those in control group, HDL-C levels were significantly lower than the control group（P 〈0.05）. FIB,Lp-PLA2 levels of unstable plaque group 〉 stable plaques 〉 no plaque group, the differences were significant（P 〈 0.05 ） among the three groups. FIB, Lp-PLA2 levels were positively correlated with Crouse integral in ACI patients （ r = 0. 514, r = 0. 813, all P 〈 0.05 ）. Conclusion It shows that FIB, Lp-PLA2 levels relate to carotid atherosclerosis in patients with acute cerebral infarction.

关 键 词：急性脑梗死 纤维蛋白原 脂蛋白相关磷脂酶(A2) 高密度脂蛋白 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]