疑似氨氯地平致全身不自主扭动1例  

Probable amlodipine-induced systemic involuntary wiggling

作　　者：杨九一[1] 顾健[1] 

机构地区：[1]北京大学人民医院,北京100044

出　　处：《临床药物治疗杂志》2015年第6期81-84,共4页Clinical Medication Journal

摘　　要：目的:查找临床1例患者全身不自主扭动的原因。方法:分析患者病情和所用药物,对药物相互作用进行分析,结合药物使用变化和患者病情变化进行综合分析。结果:该患者出现的全身及四肢的不自主扭动的情况可能与氨氯地平的剂量大有关。结论:在使用氨氯地平的中老年患者中,如果每日用量为10 mg qd甚至更高,并且合并使用其他可能影响氨氯地平代谢的药物如茶碱类制剂时,应该加强注意,尽量减少有可能造成氨氯地平蓄积的因素,避免类似的不良反应发生。Objective： To find the reason that caused the whole body involuntary. Methods： The case was analyzed as well as the drugs used during hospitalization. Combined with the change of disease condition and medication, the drug interactions were discussed. Results： Systemic involuntary wiggling was probably induced by Amlodipine. Conclusion： The situation when the amlodipine was used in elder people with the dosage of more than 10 mg qd and in combination with other drugs（such as theophylline） may affect the metabolism of amlodipine, which should be paid attention to. Therefore the similar adverse drug reaction could be avoided when the factors causing accumulation of amlodipine were reduced.

关 键 词：络活喜 氨氯地平 不良发应 全身不自主扭动 

分 类 号：R969.3[医药卫生—药理学]