D-二聚体和C-反应蛋白在主动脉夹层中的应用价值  

The application value of D-dimer and CRP in aortic dissection

作　　者：王岩[1] 黄玫[1] 马翔[2] 

机构地区：[1]新疆昌吉州人民医院内分泌科,新疆昌吉831100 [2]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《新疆医科大学学报》2016年第1期74-76,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区科技支疆项目(2013911118)

摘　　要：目的探讨D-二聚体（DD）和C-反应蛋白（CRP）在主动脉夹层（AD）中的应用价值。方法选取新疆医科大学第一附属医院2012年8月-2014年6月收治的AD患者160例（AD组）,其中A型58例,B型102例。选择同期住院并排除合并AD相关疾病的患者157例（对照组）。收集两组患者的一般资料、既往病史、入院时常规实验室检查,检测DD、超敏CRP、血尿酸（UA）、血小板计数（PLT）、白细胞计数（WBC）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、血糖（GLU）,并分析比较两组患者指标水平的差异。结果 AD组DD、CRP、UA、WBC、GLU水平均较对照组高,差异有统计学意义（P〈0.05）;AD组HDL-C水平较对照组低,差异有统计学意义（P〈0.05）。AD组A型患者UA、WBC、TG、CRP水平均高于B型患者,差异有统计学意义（P〈0.05）;AD组B型患者PLT水平高于A型,差异有统计学意义（P〈0.05）。多因素回归分析显示：CRP（OR=1.526,95%CI：1.094~6.129）、DD（OR=1.012,95%CI：4.004~5.020）为主动脉夹层的危险因素。结论DD、CRP与主动脉夹层具有相关性。Objective To explore the application value of D-dimer and C-reaction protein（CRP） in aortic dissection（AD）.Methods A case-control study was conducted on 160 cases with AD from August 2012 to June 2014 in the First Affiliated Hospital of Xinjiang Medical University（Type A 58 cases,Type B 102 cases）,and 157 control cases which excluded AD.The patient＇s general information,medical history,routine laboratory tests（including D-dimer,CRP levels,serum uric acid（UA）,platelets（PLT）,white blood cells（WBC）,triglycerides（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein（LDL-C）,and blood sugar（GLU） were collected to compare the differences between the two groups of indicators.Results It was showed that the AD group was significantly higher than control cases in D-dimer,CRP,UA,WBC and GLU（P〈0.05 for them）.The AD group was significantly lower than control cases in HDL-C（P〈0.05）.It was showed that the Type A group was significantly higher than Type B in UA,WBC,CRP and TG（P〈0.05 for them）.The Type A group was significantly lower than Type B in PLT（P0.05）.Stepwise multiple logistic regressions showed that CRP（OR= 1.526,95%CI：1.094~6.129） and D-dimer（OR =1.012,95%CI：4.004~5.020） significantly increased the risk of AD.Conclusion There is a correlation between AD and increasing of D-dimer or CRP level.

关 键 词：主动脉夹层 C反应蛋白 D-二聚体 

分 类 号：R543[医药卫生—心血管疾病]