DCE-MRI在颈动脉粥样硬化斑块新生血管定量测量中的应用  

Application of DCE-MRI in the quantitative measurement of neovascularization in carotid atherosclerotic plaque

作　　者：刘国明[1,2] 史浩[1] 程海超[1] 

机构地区：[1]山东大学附属千佛山医院影像科,山东济南250014 [2]山东中医药大学理工学院,山东济南250355

出　　处：《山东大学学报（医学版）》2015年第12期76-80,共5页Journal of Shandong University:Health Sciences

基　　金：山东省科技发展计划(2011GGB14095)

摘　　要：目的采用磁共振动态增强扫描(DCE-MRI)测量颈动脉粥样硬化斑块各成分容积传输常数(K^(trans))评估新生血管,为定量测量新生血管及评估斑块稳定性提供依据。方法颈动脉粥样硬化斑块患者均行MRI平扫及DCE-M RI扫描,根据各成分信号分为纤维组织组、钙化组、近期出血组和脂质核心组,后处理软件评估各组K^(trans)值。结果各组之间有不同的K^(trans)值,纤维组织组拥有较高的K^(trans)值(0.591/min)、钙化组(0.031/min)、近期出血组(0.115/min)和脂质核心组(0.048/min)拥有较低的K^(trans)值。各组之间K^(trans)值两两比较,近期出血组和脂质核心组差异无统计学意义(P>0.05),纤维组织组与钙化组、纤维组织组与近期出血组、纤维组织组与脂质核心组、钙化组与近期出血组、钙化组与脂质核心组之间差异有统计学意义(P<0.05)。结论 K^(trans)值反映各组渗透性和新生血管含量的不同,可作为定量评估斑块新生血管、评估斑块稳定性的重要依据。Objective To evaluate neovascularization by measuring the volume transfer constant（ K^（trans）） of the different components in carotid atherosclerosis plaques after DCE-MRI dynamic contrast-enhanced magnetic resonance imaging,in order to provide evidence to determine plaque stability and quantitative measurement of neovascularization. Methods A total of 41 patients with suspected atherosclerotic plaques in carotid arteries were scanned with MRI and DCE-MRI,and then divided into different groups according to each component signal： fibrosis group,calcification group,recent hemorrhage group and lipid core group. Data of dynamic enhancement were treated with a post processing procedure to evaluate and compare the volume transfer constant（ K^（trans）） of various components in the plaques. Results There were different K^（trans）values in different groups： 0. 591 / min in fibrosis group,0. 031 / min in calcification group,0. 115 / min in recent hemorrhage group,and 0. 048 / min in lipid core group. There was no difference between the lipid core and recent hemorrhage groups（ P〉0. 05）,but there were differences between the other groups（ P〈0. 05）. Conclusion K（trans） value in different components can reflect the different permeability and blood supply. It can be used as an indicator to assess the plaque stability and neovascularization.

关 键 词：DCE-MRI 颈动脉粥样硬化斑块 定量测量 新生血管 

分 类 号：R445[医药卫生—影像医学与核医学]