1例瑞舒伐他汀钙致肌酸激酶升高的病例分析  

One case of elevated creatine kinase induced by rosuvastatin calcium

作　　者：朱春梅[1] 谢小云[2] 宋洪涛[2] 赖国祥[3] 郑溢声[3] 

机构地区：[1]南京军区福州总医院第一附属医院药学科,福建莆田351100 [2]南京军区福州总医院药学科,福建福州350025 [3]南京军区福州总医院呼吸与危重症医学科,福建福州350025

出　　处：《中国药物应用与监测》2015年第6期390-392,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：1例69岁男性患者,因反复咳嗽、咳痰3周入院,既往有颈动脉硬化症病史,入院前及入院后第2天查肌酸激酶均正常,7 d后复查发现肌酸激酶异常升高。临床药师从患者的身体状况、药品不良反应、药物相互作用等方面分析肌酸激酶升高的可能原因,考虑因瑞舒伐他汀钙合并用药引起的可能性较大,建议医生立即停用瑞舒伐他汀钙,并嘱患者多饮水以促进药物的排出。3 d后复查提示肌酸激酶恢复到正常值。One 69-year-old male patient was admitted to the hospital with repeatedly cough and expectoration for 3 weeks. The patient had a history of carotid sclerosis. The levels of creatine kinase were normal before and at the second day after admission, but on the seventh day of admission, the abnormally increased creatine kinase was found. Clinical pharmacists analyzed the possible reasons of elevated creatine kinase from the patient’s physical condition, drug combination, drug interaction, and adverse drug reaction. Clinical pharmacists considered that the reason was more likely due to the combination use of rosuvastatin calcium with other drugs, suggested stopping rosuvastatin calcium immediately, and told the patient to drink more water. The level of creatine kinase returned to normal 3 days later.

关 键 词：瑞舒伐他汀钙 肌酸激酶 合并用药 临床药师 药品不良反应 

分 类 号：R972[医药卫生—药品]