细辛脑注射液治疗儿童呼吸系统疾病的有效性及安全性的系统评价  

Evaluate the efficacy and safety of asarone injection in treating children with respiratory diseases

作　　者：刘砚韬[1,2,3] 张伶俐[1,2,3] 黄亮[1,2,3] 曾力楠[1,2,3] 

机构地区：[1]四川大学华西第二医院药学部,成都610041 [2]四川大学华西第二医院循证药学中心,成都610041 [3]四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2015年第6期689-697,共9页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(81373381);教育部长江学者创新团队基金(IRT0935)~~

摘　　要：目的系统评价细辛脑注射液治疗儿童呼吸系统疾病的有效性和安全性。方法计算机检索MEDLINE数据库、Cochrane图书馆临床对照试验库（CENTRAL）、维普数据库（VIP）、中国期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）及万方数据库等中、英文数据库,检索年限为各数据库自建库至2014年6月,同时结合手工检索,获得关于细辛脑注射液治疗儿童呼吸系统疾病的随机对照试验（RCT）研究文献。由2位经该项目培训合格的研究者,对纳入文献进行资料提取、质量评价及交叉核对。采用RevMan 5.2软件,对细辛脑注射液治疗儿童呼吸系统疾病的有效性和安全性进行meta分析。结果经检索,共计14篇关于细辛脑注射液治疗儿童呼吸系统疾病的有效性和安全性的RCT研究文献纳入本研究,纳入患儿共计1 839例。纳入文献中4篇为中等质量研究文献,10篇为低质量研究文献。本研究meta分析结果显示：1细辛脑注射液能有效治疗儿童毛细支气管炎、肺炎、支气管炎和喘息性疾病。2在治疗儿童毛细支气管炎方面,细辛脑注射液的总有效率优于氨茶碱（RR=1.25,95%CI：1.13~1.38,P〈0.000 1）或鱼腥草（RR=1.32,95%CI：1.12~1.56,P=0.001 0）,但尚不能认为其优于抗病毒药物利巴韦林（RR=1.25,95%CI：0.86~1.83,P=0.250 0）。3在治疗儿童肺炎方面,细辛脑注射液的总有效率优于利巴韦林（RR=1.14,95%CI：1.04~1.25,P=0.005）或抗菌药物（RR=1.19,95%CI：1.04~1.40,P=0.040）。4在治疗儿童支气管炎方面,细辛脑注射液的总有效率优于氨茶碱（RR=1.17,95%CI：1.04~1.32,P=0.01）,尚不能认为其优于氨溴索（RR=1.09,95%CI：0.99~1.19,P=0.07）或对症治疗（RR=1.19,95%CI：0.94~1.51,P=0.15）。5在治疗毛细支气管炎、哮喘并肺部感染等儿童喘息性疾病方面,细辛脑注射液的总有效率高于炎琥宁,且差异有统计学意义（97.6%vs 90.3%,χ^2=11.12,P〈0.01）。6在安Objective System assessment of the efficacy and safety of asarone injection in treating children with respiratory diseases.Methods All the randomized controlled trials（RCT）about treating children with respiratory disease with asarone injection were collected by searching MEDLINE database,Cochrane Central Register of Controlled Trials（CENTRAL）,VIP database,China National Knowledge Infrastructure（CNKI）database,China Biology Medicine（CBM）and Wanfang database,retrieval time from the database creation to June 2014,meanwhile combined with manual search.The data extraction of the included studies,assessment of methodological quality and cross check were performed independently by two reviewers who were trained by the project.Meta-analysis was conducted to evaluate the efficacy and safety of asarone injection in treating children with respiratory diseases with RevMan 5.2 software.Results A total of 14 RCTs about treating children with respiratory disease with asarone injection were included and involving 1 839 children.4 of 14 RCTs were ordinary quality,and another 10 RCTs were low quality.The results of meta-analysis showed that：1 Asarone injection was effective in treating children with respiratory diseases including bronchiolitis,pneumonia,bronchitis and asthmatic disease;2 In treating children with bronchiolitis,the total effective rate of asarone injection was superior to aminophylline（RR=1.25,95%CI：1.13-1.38,P〈0.000 1）and houttuynia cordata（RR=1.32,95%CI：1.12-1.56,P=0.001 0）,but can not think it superior to ribavirin（RR=1.25,95%CI：0.86-1.83,P=0.250 0）;3In treating children with pneumonia,the total effective rate of asarone injection was superior to ribavirin（RR=1.14,95%CI：1.04-1.25,P=0.005）and antibacterials（RR=1.19,95%CI：1.04-1.40,P=0.040）;4 In treating children with bronchitis,the total effective rate of asarone injection was superior to aminophylline（RR=1.17,95%CI：1.04-1.32,P=0.01）,but can not think it superior to ambroxol（RR=1.09,95%CI：0.99-1.19,P=0.07

关 键 词：细辛脑 呼吸道疾病 META分析 系统评价 儿童 

分 类 号：R725.6[医药卫生—儿科]