肝胆疾病患者输血前不规则抗体筛查的相关分析研究  

Correlation analysis of irregular antibody screening before transfusion in patients with hepatobiliary disease

作　　者：杨孝亮 俞文隆[2] 王爱华[1] 周小琴[3] 高春芳[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院实验诊断科,上海200438 [2]第二军医大学附属东方肝胆外科医院胆道二科 [3]第二军医大学附属东方肝胆外科医院腹腔镜科

出　　处：《临床血液学杂志（输血与检验）》2015年第6期1030-1032,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的：分析肝胆疾病患者输血治疗前不规则抗体筛查阳性结果的分布特点及其特异性。方法：回顾性分析2013-05-01-2014-12-31检测的17 189例肝胆疾病患者不规则抗体筛查及筛查阳性的抗体鉴定结果。结果：在52例（0.30%）不规则抗体筛查阳性肝胆疾病患者中,男14例（0.12%）,女38例（0.66%）,女性明显高于男性（χ~2=36.413,P〈0.01）;其中Rh系统有24例（46.15%）,血清学表型主要以CCDee（23.08%）为主;MNS系统有18例（34.62%）,血清学表型主要以NN（34.62%）为主;在肝胆专科疾病分类中主要以原发性、转移性肝癌（51.92%）为主,其次为肝内外胆管结石、胆囊结石（30.77%）。结论：不规则抗体的筛查可以有效预防和减少肝胆疾病患者输血不良反应的发生,确保临床输血更加安全、有效。Objective：To analyze the distribution and specificity of the antibody screening result for the hepatobiliary disease patients before the transfusion therapy.Method：The results of irregular antibody screening in the17,189 patients with hepatobiliary disease in our hospital during Jan 1 2013 and Dec 31 2014 were retrospectively analyzed,Result：In 52 cases（0.30%） of hepatobiliary disease patients with the irregular antibody screening positive,there were 14 males（0.12%） and 38 females（0.66%）,the proportion of females were significantly higher than that of males（χ~2= 36.413,P〈0.01）,Among them,Rh system accounted for 24 cases（46.15%）,with the mainly serological phenotype of CCDee（23.08%）;MNS system accounted for 18 cases（34.62%） with the mainly serological phenotype of NN（34.62%）.With the respect of the hepatobiliary disease classification,the positive irregular antibody result were mainly in the patients with primary or metastatic liver cancer（51.92%）,followed by extrahepatic bile duct stones and cystic calculi（30.77%）.Conclusion：Screening of irregular antibodies could effectively prevent and reduce the occurrence of severe adverse reactions to ensure that the clinical transfusion be safer and effective in the blood transfusion therapy for the patients with hepatobiliary disease.

关 键 词：肝胆疾病 不规则抗体 安全输血 

分 类 号：R256.4[医药卫生—中医内科学]