巨噬细胞极化与动脉粥样硬化  

Macrophage polarization and atherosclerosis

作　　者：袁锋[1] 尚茹茹 张锦[3] 温婷[1] 李爱萍[4] 刘晓红[3] 

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学第一医院心血管内科,太原030000 [3]山西省人民医院老年医学科,太原030000 [4]上海市江湾医院心内科,200434

出　　处：《中华临床医师杂志（电子版）》2015年第22期94-97,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省卫生厅基础研究计划项目(2014011043-5)

摘　　要：动脉粥样硬化是一种大中动脉壁的慢性炎症疾病,巨噬细胞参与了动脉粥样硬化的整个过程,病变中初始巨噬细胞在微环境极化因子的诱导下,改变自身表型和功能,极化为经典M1、替代M2型Mφ,两个表型及功能不同的巨噬细胞的相对比例影响动脉粥样硬化的进展及消退。下面就动脉粥样硬化中巨噬细胞极化、极化调节及二者与动脉粥样硬化关系进行综述,以期寻找新的治疗动脉粥样硬化的方法。Atherosclerosis is a chronic inflammatory disease of large- and medium-sized arteries, and macrophages are involved in the whole process of atherosclerosis. The initial macrophages in the atherosclerotic lesions can be induced by the polarization factors in micro-environment and alter their phenotypes and functions resulting in a subsets system--the classical M1 macrophages, the alter-native M2 macrophages. The relative proportions of the two subtypes of macrophages with different phenotypes and functions influence the progression and regression of lesions. To find new method for the prevention and treatment of atherosclerosis, this review covered our current knowledge on macrophage polarization, polarization regulation, and their relationship with atherosclerosis.

关 键 词：动脉粥样硬化 巨噬细胞极化 失衡 极化调节 

分 类 号：R543.5[医药卫生—心血管疾病]