姜黄素缓解动物急性肺损伤的研究现状  

Current understanding of the roles of curcumin on relieving the acute lung injury in animal models

作　　者：谭远辉[1] 刘健[1] 朱四海[1] 

机构地区：[1]南京军区南京总医院麻醉科,210002

出　　处：《中华临床医师杂志（电子版）》2015年第23期168-171,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：南京军区南京总医院重点课题基金项目(YYZD2014001)

摘　　要：姜黄素是从姜黄中提取的一种活性成分,具有抗炎、抗氧化、抗凋亡和免疫调节等作用。急性肺损伤是以急性重度的肺弥散功能障碍为特征的重症,表现为炎性细胞的浸润、过氧化物的释放、内皮细胞的损伤和大量促炎因子的产生等。研究发现姜黄素能缓解多种因素导致的动物急性肺损伤,本文对该领域的研究现状作一综述。Curcumin is an active ingredient extracted from turmeric, which has the effect of anti-inflammatory, antioxidation, antiapoptosis, immune regulation and so on. Acute lung injury is a critical syndrome characterized by acute severe dysfunction of the diffusion of lung. The pathologic changes include the infiltration of inflammatory cells, the release of peroxide, the injury of endothelial cells, the production of proinflammatory factors and so on. It has been demonstrated that curcumin could attenuate the acute lung injury in animal models. This review summarized the current understanding in this field.

关 键 词：姜黄素 呼吸窘迫综合征 成人 模型 动物 

分 类 号：R259[医药卫生—中西医结合]