固有免疫和适应性免疫与慢性丙肝的研究进展  

Studies about Innate and Adaptive Immune Responses on Chronic Hepatitis C

作　　者：王方平[1] 张平安[1] 牛志立[1] 

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《现代检验医学杂志》2015年第6期6-9,共4页Journal of Modern Laboratory Medicine

摘　　要：固有免疫应答是抵抗病毒入侵的第一道防线，启动后产生一系列的细胞因子如干扰素等发挥作用，6-8周后，适应性免疫应答才被检测到。经过抗原刺激后，活化、增殖的效应细胞如CD4＋和CD8＋T细胞、调节性T细胞和自然杀伤细胞，产生效应分子如抗体和细胞因子而发挥作用。虽然有固有免疫和适应性免疫应答机制，大多数丙型肝炎病毒感染者仍不能清除病毒，会发展为慢性持续性感染。该文就固有免疫和适应性免疫在慢性丙型肝炎发病机制中的作用进行综述。Innate immune responses are the first line of delense against viral refections ann atter actlvateo it would prouuce a series of cytokines such as interferon （IFN） to function. 6-8 weeks later, the adaptive immune response can be detected. After being antigen stimulated, the effectors cells are activated and proliferated, such as CD4＋and CD8＋ T cells, Regulatory T cell,and generate effector molecules （such as antibodies,eytokines） to function. Although there are innate and adaptive immune responses mechanisms,most HCV-infected patients are still unable to clear the virus and develop viral persistence. In this review,summarize the role of innate immunity and adaptive immunity in chronic hepatitis C pathogenesis.

关 键 词：慢性丙型肝炎 固有免疫 适应性免疫 

分 类 号：R392.11[医药卫生—免疫学] R512.63[医药卫生—基础医学]