盐酸羟考酮注射液在腔镜手术后镇痛的临床应用  

Clinical application of Oxycodone hydrochloride injection to analgesia after laparoscopic surgery

作　　者：缪小勇[1] 徐葭[1] 曹建平[1] 

机构地区：[1]解放军第四五五医院麻醉科,上海200052

出　　处：《临床军医杂志》2015年第8期781-783,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨盐酸羟考酮注射液和电子输液泵不同的参数设置用于腔镜手术后镇痛的有效性和安全性。方法选择120例腔镜下手术术后镇痛患者,随机分成两组:枸橼酸舒芬太尼镇痛组(S组,n=60),盐酸羟考酮镇痛组(O组,n=60)。S组PCA泵方案:舒芬太尼0.1 mg+0.9 NS=100 ml,1μg/ml;背景剂量2 ml/h,单次给药剂量2 ml,锁定时间15 min。O组PCA泵方案:羟考酮50 mg+0.9 NS=100 ml,0.5 mg/ml;背景剂量2 ml/h,单次给药剂量2 ml,锁定时间5 min。比较两组患者术后2、4、8、12、24、48 h各时间点的静态和动态VAS值;比较两组术后恶心呕吐、尿潴留、皮疹不良事件的发生率;比较两组患者术后PCA人均总按压次数、有效按压次数、无效按压次数;比较两组患者镇痛满意度(满意、可接受、不满意)。结果两组患者术后各时间点静态和动态VAS值比较差异无统计学意义(P>0.05);O组术后恶心呕吐、尿潴留的发生率明显高于S组,差异有统计学意义(P<0.01);O组PCA总按压次数、无效按压次数明显减少,差异有统计学意义(P<0.05);O组满意度明显高于S组,差异有统计学意义(P<0.01)。结论羟考酮用于腔镜手术的术后镇痛效果良好,明显降低不良反应。Objective To investigate the efficacy and satety of Oxycodone hydrochloride injection and electronic iniusion pump of different parameter Settings for analgesic of laparoscopic surgery. Methods Totally 120 patients with postoperative analgesia after the laparoscopic surgery were randomly divided into two groups：the analgesia group of Sufentanil （Group S, n = 60） , the analgesia group of Oxyeodone hydrochloride（Group O,n =-60）. Group S PCA pump scheme：sufentanil 0.1 mg ＋ 0.1 NS = 100 ml,1 μg/ml; Background dose of 2 ml/h, single drug dose 2 ml,locking time 15 minutes;Group O PCA pump scheme：Oxycodone 50 mg ＋ 0.9 NS = 100 m1,0.5 mg/ml ; Background dose of 2 ml/h, single drug dose 2 ml, lock time 5 minutes; Comparison of patients between the two groups after 2,4,8,12,24 and 48 hours of static and dynamic VAS each time point, and postoperative nausea and vomiting, urinary retention, rash and the incidence of adverse events in patients of the two groups were observed and compared;Postoperative PCA per capita number of total pressure, effective number of press number, invalid press in patients of the two groups were compared; Analgesia satisfaction（ satisfaction, acceptable, not satisfied） in patients of the two groups were also compared. Results VAS of patients in two groups with postoperative static and dynamic each time point had no statistical significance （ P 〉 0. 05 ） ; The incidence of postoperative nausea and vomiting, urinary retention in Group O was significantly higher than that in Group S（ P 〈 0.01 ） ; PCA total number of press number, invalid press in patients of Group O decreased significantly（ P 〈 0.05 ） ;Satisfaction of Group O was obviously higher than that of Group S （P 〈 0.01 ）. Conclusion Postoperative analgesia to Oxycodone of laparoscopic surgery made good analgesia effect, which can significantly reduce adverse reaction.

关 键 词：羟考酮注射液 腔镜手术 电子输液泵 VAS评分 

分 类 号：R971.1[医药卫生—药品]