预防服用维生素B_6联合氯苯那敏对荧光素眼底血管造影后不良反应的影响  

Effect of Prophylactic Use of Vitamin B_6 with Chlorpheniramine on the Adverse Reactions in Fundus Fluorescein Angiography

作　　者：朱俊峰[1] 谢晓露[1] 刘昕宇[1] 林洪杰[1] 

机构地区：[1]汕头大学.香港中文大学联合汕头国际眼科中心,广东汕头515041

出　　处：《中国药房》2015年第36期5069-5071,共3页China Pharmacy

基　　金：汕头市医疗重点科技计划项目

摘　　要：目的:探讨预防服用维生素B6联合氯苯那敏对荧光素眼底血管造影后不良反应的影响。方法:326例行荧光素眼底血管造影的患者随机均分为观察组和对照组。荧光素眼底血管造影前30 min,观察组患者给予维生素B6片10 mg,口服+马来酸氯苯那敏片4 mg,口服;对照组患者给予甲氧氯普胺片10 mg,口服+马来酸氯苯那敏片4 mg,口服。观察两组患者不良反应发生时间、发生率,并作相关性分析。结果:两组患者不良反应发生时间比较,差异无统计学意义(P>0.05);观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。对照组患者不良反应的发生与患者年龄、性别无相关性(P>0.05)。结论:荧光素眼底血管造影前给予维生素B6联合马来酸氯苯那敏可减少不良反应的发生。OBJECTIVE：To explore the effect of prophylactic use of vitamin B6 with chlorpheniramine on the adverse reactions in fundus fluorescein angiography （FFA）. METHODS：326 patients with FFA were randomly divided into observation group and control group. Observation group was orally given Vitamin B6 tablet 10 mg 30 min before angiography＋Chlorpheniramine maleate tablet 4 mg;control group was orally given Metoclopramide tablet 10 mg＋Chlorpheniramine maleate tablet 4 mg. The occurrence time and incidence of adverse reactions in 2 groups were observed and correlation analysis was conducted. RESULTS：There was no significant difference in the occurrence time of adverse reactions between 2 groups（P〈0.05）;the incidence of adverse reactions in observation group was significantly lower than control group,the difference was statistically significant（P＆lt;0.05）. The correlation analysis of adverse reactions in control group showed the occurrence of adverse reactions had no correlation with age and gender of patients（P〈0.05）. CONCLUSIONS：Prophylactic use of vitamin B6 with chlorphenir arnine can reduce the occurrence of adverse reactions in FFA.

关 键 词：荧光素眼底血管造影 预防服药 不良反应 维生素B6 氯苯那敏 

分 类 号：R770[医药卫生—眼科]