HIV/AIDS患者治疗前后补体C1q水平及相关实验室指标检测结果分析  

Analysis of serum complement C1q levels in combination with other laboratory parameters in HIV/AIDS patients prio-and post-treatment

作　　者：罗晓璐[1] 苏国生[1] 韦礼斌[1] 韦善求 刘泽端[1] 梁娟英[1] 罗顺达[1] 黄宛虹 倪祖彦 

机构地区：[1]南宁市第四人民医院广西医科大学附属南宁市传染病医院广西艾滋病临床治疗中心(南宁)检验科,广西530023

出　　处：《中国临床新医学》2015年第12期1136-1138,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：南宁市科学研究与技术开发计划项目(编号:20123164);广西卫计委科研课题(编号:Z2012622)

摘　　要：目的了解HIV／AIDS患者治疗前后补体Clq水平及相关实验室指标检测结果的变化情况。方法选取2011-09-2014-10在广西艾滋病临床治疗中心（南宁）进行抗逆转录病毒治疗的患者共96例。观察所有病例处于基线时和治疗6个月后血清补体C1q水平及其他相关实验室指标检测结果变化情况。结果HIV／AIDS患者抗病毒治疗后补体C1q总浓度水平比治疗前降低，差异具有统计学意义（P〈0．05）；治疗后补体C1q浓度升高者33例，不变或降低者63例，升高例数和降低例数比较差异具有统计学意义（P〈0．05）；治疗后6个月CD3、CD4、CD8、CIM／CD8、病毒载量检测结果与治疗前比较，CD3、CD4、CD8、CD4／CD8的检测结果升高，病毒载量的检测结果降低，差异具有统计学意义（JP〈0．01）。结论HIV／AIDS患者治疗前后联合检测补体C1q水平及相关实验室指标对指导临床治疗具有重要的意义。Objective To elucidate the serum levels of complement C1 q and their correlation with other la- boratory parameters in HIV/AIDS patients prior- and post-treatment. Methods A retrospective study was performed in which 96 HIV/AIDS patients were included from September 2011 to October 2014 in the Fourth People＇s Hospital of Nanning in Guangxi Zhuang Autonomous Region and were treated with antiretroviral therapy. The serum comple- ment Clq and other laboratory parameters in the patients were detected and analyzed before and 6 months after the treatment. Results The concentration of serum ~omplement Clq was significantly reduced in HIV/AIDS patients af- ter antiretroviral therapy （P 〈 0.05 ）. Among them, the serum C1 q level was elevated in 33 cases after 6 months of the treatment comparing to 63 cases who showed serum Clq reduction（ P 〈 0.05 ）. Blood CD3, CD4, CD8 counts, and CD4/CD8 ratio were elevated while the viral load testing results showed decrease after the treatment comparing with those before the treatment（ P 〈0. 01 ）. Conclusion Combination analysis of serum Clq level, T lymphocyte subsets, and viral load is a new and useful clinical laboratory diagnostic strategy and should be considered as a routine monitoring parameter set in HIV/AIDS treatment and prognosis.

关 键 词：人类免疫缺陷病毒 获得性免疫缺陷综合征 补体C1Q T淋巴细胞亚群 病毒载量 

分 类 号：R512.91[医药卫生—内科学]