痰热清注射液对合并COPD肺癌患者围手术期TNF-α、IL-6、IL-8和IL-10的影响  

Effect of Tan-Re-Qing Injection on Perioperative Period of TNF-α, IL-6, IL-8 and IL-10 in Lung Cancer Patients Complicated with COPD

作　　者：熊国江[1] 吴俊宏[1] 吕伟[1] 尚龙华 熊汉鹏[1] 刘小雄[1] 王丽华[1] 

机构地区：[1]江西中医药大学附属医院,南昌330006 [2]南昌市中西医结合医院,南昌330006

出　　处：《世界科学技术-中医药现代化》2015年第10期2083-2087,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江西省卫生计生委中医药科研计划(2013B033):痰热清注射液对合并COPD肺癌患者围手术期TNF-α;IL-6;IL-8和IL-10的影响;负责人:熊国江

摘　　要：目的:探讨痰热清能否减轻合并COPD肺癌患者术后炎性反应和肺损伤的程度。方法:选择39例合并COPD肺癌患者(痰热瘀肺型),随机分为被试组18例和对照组21例。所有患者行胸腔镜辅助下小切口手术。对照组用西医常规治疗,被试组加用痰热清注射液。在术前1天(T1)、术后第1天(T2)、第3天(T3)、第7天(T4)采集血清标本,测定两组血清中TNF-α、IL-6、IL-8和IL-10的浓度。结果:在T1、T2时间,两组患者体内TNF-α、IL-6、IL-8和IL-10水平比较无显著性差异(P>0.05);在T3时间,被试组患者体内TNF-α、IL-6和IL-8水平低于对照组,差异具有统计学意义(P<0.05),被试组患者体内IL-10水平高于对照组,差异具有统计学意义(P<0.05);在T4时间,被试组患者体内TNF-α、IL-6和IL-8水平低于对照组,差异具有统计学意义(P<0.05);两组患者在T3、T4时间TNF-α、IL-6、IL-8水平逐渐下降,与T2时间水平比较及相互比较,差异具有统计学意义(P<0.05)。结论:痰热清注射液能减少合并COPD肺癌围手术期间炎性细胞因子的释放,增加抗炎因子生成,从而减轻炎性反应程度,减轻肺脏损伤,保护肺功能。This study was aimed to explore the possibility of reducing postoperative inflammatory response and lung injury degree by observing the effect of Tan-Re-Qing（TRQ） Injection on perioperative period of lung cancer patients complicated with chronic obstructive pulmonary disease（COPD）. A total of 39 lung cancer cases complicated with COPD（phlegm-heat obstructing the lung） were randomly divided into the tested group of 18 cases and the control group of 21 cases. All patients underwent small incision surgery with video-assisted thoracoscopic surgery（VATS）. The control group was treated with routine western medicine. TRQ injection was added in the tested group. On the preoperative 1D（T1）, 1D after operation（T2）, 3D after operation（T3）, 7D after operation（T4）, serum samples were collected for the determination of serum concentrations of TNF-α, IL-6, IL-8 and IL-10. At T1 and T2 time, there were no significant differences on levels of TNF-α, IL-6, IL-8 and IL-10 between two groups of patients（P〉0.05）. At T3 time, levels of TNF-α, IL-6, IL-8 of the tested group were lower than that of the control group with statistical significance（P〈0.05）. The level of IL-10 in the tested group was higher than that of the control group with statistical significance（P〈0.05）. At T4 time, the levels of TNF-α, IL-6 and IL-8 of the tested group were lower than that of the control group with statistical significance（P〈0.05）. The levels of TNF-α, IL-6 and IL-8 of both groups gradually declined at T3 and T4 time, compared with T2 time level with statistical significant（P〈0.05）. It was concluded that TRQ injection reduced the releasing of inflammatory cytokines during perioperative period, increased levels of anti-inflammatory cytokine, thereby reducing the degree of inflammatory reaction and relieving lung injury for the protection of lung function of lung cancer patients complicated with COPD.

关 键 词：痰热清注射液 合并COPD肺癌 炎性细胞因子 肺损伤 

分 类 号：R273[医药卫生—中西医结合]