中药联合双磷酸盐治疗恶性肿瘤骨转移疗效的Meta分析  

Traditional Chinese Medicine Decoction Combined Bisphosphonates in Treatment of Bone Metastasis of Malignant Tumors: A Systematic Reviews and Meta-analysis

作　　者：王胜飞[1,2] 王芹[1] 付艳丽[1] 焦丽静[1] 王青[1] 许玲[1] 张杰[1,2] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]复旦大学附属肿瘤医院,上海200032

出　　处：《世界科学技术-中医药现代化》2015年第10期2136-2144,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金面上项目(81373623):工程控制算法引导下的"金复康"优化及其抗肿瘤血管生成机制研究;负责人:许玲;国家中医临床研究基地"龙医团队;龙医学者"项目(D25):肿瘤相关巨噬细胞对肺癌侵袭作用的中药单体干预及机制研究;负责人:张杰;上海市闵行区卫生和计划生育委员会科研课题(2014MW24):中药熏蒸治疗联合唑来膦酸治疗骨转移相关疼痛的随机双盲研究;负责人:王芹

摘　　要：目的:通过对比双磷酸盐联合传统中药汤剂与单纯双磷酸盐治疗恶性肿瘤骨转移的疗效,来验证传统中医药治疗恶性肿瘤骨转移的作用和优势。方法:计算机检索Pub Med、Embase、CBM、CNKI和Cochrane Databases中的相关文献,结局指标包括疼痛缓解评价、活动能力改善评价、骨质修评价、KPS改善评价以及毒副反应。运用Meta分析软件Stata 11.0进行统计分析。结果:共纳入研究19篇,涉及患者人数为1 080,结果提示双磷酸盐联合传统中药汤剂组能显著改善疼痛症状(RR=0.807 9,95%CI=0.754-0.85,P<0.001)、改善活动能力(RR=0.787,95%CI=0.69-0.897,P<0.001)、改善骨质破坏(RR=0.71,95%CI=0.52-0.96,P=0.026)、提高KPS(RR=0.726 8,95%CI=0.61-0.85,0.58-0.81,P<0.001)。结论:双磷酸盐联合传统中药汤剂治疗恶性肿瘤骨转移能够显著提高其疗效,同时改善患者的生活质量。This study was aimed to systematically appraise the effectiveness and safety of traditional Chinese medicine（TCM） decoction in combination with bisphosphonates in treatment of bone metastasis of malignant tumors. Related literatures were searched in the Pub Med, Embase, CBM, CNKI and Cochrane Databases. The endpoints included cancer pain, activity of daily living, sclerotin reparation, KPS and adverse events. The Stata 11.0 software was used in the statistical analysis. The results showed that a total of 19 articles involving 1080 patients were included. It showed that TCM in combination with bisphosphonates can significantly relieve pain（RR = 0.8079, 95%CI = 0.754- 0.85, P〈0.001）, improve the activity of daily living（RR = 0.787, 95%CI = 0.69-0.897, P〈0.001）, promote sclerotin reparation（RR = 0.71, 95%CI = 0.52-0.96, P = 0.026）, and improve KPS（RR = 0.7268, 95%CI = 0.61-0.85, 0.58-0.81, P〈0.001）. It was concluded that TCM decoction in combination with bisphosphonates can significantly improve its therapeutic effect as well as improve the patients＇ quality of life.

关 键 词：中药汤剂 双磷酸盐 恶性肿瘤 骨转移 META分析 

分 类 号：R979.1[医药卫生—药品]