串联混合输注装置中丙氨酰谷氨酰胺配伍稳定性考察  

Study on Compatibility Stability of Alanylglutamine by Using Continuous Series Infusion Device

作　　者：张程亮[1] 冯承阳 徐艳娇[1] 余早勤 刘东[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2015年第12期1657-1659,共3页Herald of Medicine

摘　　要：目的考察串联混合输注装置中丙氨酰谷氨酰胺的配伍稳定性,为合理输注丙氨酰谷氨酰胺提供实验依据。方法选取临床常与丙氨酰谷氨酰胺配伍的两种氨基酸注射液,经串联输注装置连接后滴注,测定不同时刻流出的输注液p H值、渗透压、不溶性微粒数和丙氨酰谷氨酰胺含量。结果在串联混合输注方式下,实验各配伍组p H值、不溶性微粒数量随时间变化不明显,但渗透压和丙氨酰谷氨酰胺含量在输注0.5 h时变化较大。结论串联混合输注装置在整个输注过程中不能很好混匀丙氨酰谷氨酰胺和氨基酸注射液,建议尽可能提前混匀各配伍溶液以保证输注过程中丙氨酰谷氨酰胺的稀释比例和配伍液渗透压的稳定性。Objective To investigate the compatible stability of alanylglutamine by using continuous series infusion device,and provide experimental evidence for reasonable clinical use of alanylglutamine. Methods p H,osmolality and quantity of insoluble particles were measured by using p H meter, automatic freezing osmometer and intelligent particle detector respectively.A HPLC method was built for the determination of the content of alanylglutamine. Results p H and quantity of insoluble particles of the two tested groups did not change significantly over time. Osmolality and the content of alanylglutamine fluctuated greatly in the first half an hour. Conclusion Continuous series infusion device may not mix each bottle of solution very well.It is suggested to premix these solutions to ensure the stability of the dilution ratio and the osmotic pressure of the mixture in the process of the infusion.

关 键 词：丙氨酰谷氨酰胺 串联混合输注装置 稳定性 配伍 

分 类 号：R977.2[医药卫生—药品] R969.3[医药卫生—药学]