补肾化痰方干预糖尿病认知障碍的量效研究  

Observation of Curative Effect by Different Doses of Bushenhuatanfang in Rats with Diabetes Mellitus

作　　者：赵厚睿[1] 戴红[1] 杨旻[1] 

机构地区：[1]湖北中医药大学基础医学院,湖北武汉430065

出　　处：《时珍国医国药》2015年第12期2887-2889,共3页Lishizhen Medicine and Materia Medica Research

基　　金：湖北省教育厅教育教学基金重点项目(D20132004)

摘　　要：目的研究不同剂量的补肾化痰方对糖尿病大鼠学习记忆功能的干预情况。方法将3月龄雄性Wistar大鼠分为对照组、模型组、补肾化痰方干预组(分为高、中、低剂量三组),模型组和补肾化痰方干预组用链脲佐菌素35mg·kg-1剂量腹腔注射,对照组腹腔注射相同体积的枸椽酸缓冲液,补肾化痰方干预组分别使用20,10,5g·kg-1的补肾化痰方腹腔注射,采用水迷宫实验观察糖尿病大鼠的行为学改变。结果造模后模型组和补肾化痰方干预组大鼠血糖较对照组显著升高(P﹤0.01),实验处理后中剂量组血糖水平最低。Morris水迷宫检测大鼠到达站台时间显示,模型组需时间较对照组所需时间明显延长,具有显著性差异(P﹤0.01);补肾化痰方干预组各组所需时间低、中、高剂量组均较模型组明显减少(P﹤0.01),且中剂量组所需时间最少。结论补肾化痰方能够有效降低糖尿病大鼠的血糖水平,并能改善其认知功能障碍,且中剂量组疗效最好。Objective To study the influence of different doses of Bushenhuatanfang on diabetes mellitus and cognitive impairment in rats. Methods We used Bushenhuatanfang to treat rats with diabetes mellitus and cognitive impairment. We observed the change of rat＇s ability of learning and memory function,by the application of water maze. Results All doses of Bushenhuatanfang could reduce rats serum glucose and significantly reduce the swimming time to platform,and the effect of mild dose was best. Conclusion Bushenhuatanfang could improve diabetes mellitus rat＇s cognitive impairment,and mild dose of it was best.

关 键 词：补肾化痰方 糖尿病 认知功能障碍 

分 类 号：R285.5[医药卫生—中药学]