凉血解毒化瘀方治疗乙肝相关慢加急性肝衰竭的临床研究  

Clinical Research on Liangxue Jiedu Huayu Formula in the Treatment of HBV-related acute on chronic liver failure

作　　者：刘丽[1] 李芹[1] 林恢[1] 刘政芳[1] 黄伟[1] 

机构地区：[1]福州市传染病医院,福建福州350025

出　　处：《时珍国医国药》2015年第12期2936-2937,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家"十二五"传染病重大专项课题(No.20122012ZX10005005-001-017)

摘　　要：目的对乙型肝炎相关慢加急性肝衰竭中西医结合疗法进行探讨。方法 58例乙型肝炎相关慢加急性肝衰竭湿热瘀黄证患者,随机分为试验组和对照组。28例对照组患者行西医常规内科治疗,疗程4周,必要时行人工肝支持治疗,而30例试验组则在对照组的基础上加用凉血解毒化瘀方治疗。结果 30例试验组患者总有效率86.6%;而28例对照组患者总有效率75%,两组患者疗效比较有显著差异(P<0.05)。两组治疗后,试验组肝功恢复情况与对照组比较,差异具有统计学意义(P<0.05);与本组治疗前比较,两组治疗后终末期肝病模型(MELD)评分均下降,具有显著差异(P<0.05);治疗后两组肾功能(尿素氮、肌酐)比较有显著差异(P<0.05)。结论凉血解毒化瘀方可以改善乙型肝炎相关慢加急性肝衰竭湿热瘀黄证患者肝功能,提高临床疗效。Objective To discuss the therapeutic effect of integrated Traditional Chinese and Western on HBV-related acute on chronic liver failure（ HBV-ACLF）. Methods 58 cases of HBV-ACLF patients,randomly divided into experimental group and control group. 28 cases in control group patients with Western medicine routine medical treatment for 4 weeks,when necessary to make artificial liver support therapy,while in the control group 30 cases of patients combined with Liangxue Jiedu Huayu Formula of treatment for 4 weeks. Results 30 cases of experimental group total effective rate was 86. 6%; And 28 patients in the control group total effective rate was 75%,two groups of patients with significant differences（ P〈0. 05）. Two groups after 4weeks treatment,the experimental liver result recovery compared with control group,difference has statistical significance（ P〈0. 05）; Compared with previous this treatment,the two groups after treatment model for end-stage liver disease（ MELD） scores decreased were significant difference（ P〈0. 05）; In the two groups after treatment of renal function（ urea nitrogen,creatinine）were significant differences（ P〈0. 05）. Conclusion Liangxue Jiedu Huayu Formula can improve the HBV-ACLF patients with liver function and improve clinical curative effect.

关 键 词：乙型肝炎相关慢加急性肝衰竭 终末期肝病模型评分 中西医结合治疗 

分 类 号：R289.5[医药卫生—方剂学]