体重指数对绝经前后Luminal型乳腺癌预后的影响分析  

Analysis of the influencing of Body Mass Index on prognosis in premenopausal and postmenopausal luminal breast cancer

作　　者：赵敏[1] 李卉[2] 陶苹[2] 李卉[1] 谭婧[1] 刘芳[1] 李佳圆 

机构地区：[1]四川大学华西公共卫生学院(华西第四医院),四川成都610041 [2]四川省第二人民医院(四川省肿瘤医院)乳腺科,四川成都610041

出　　处：《现代预防医学》2015年第24期4434-4437,共4页Modern Preventive Medicine

摘　　要：目的探讨体重指数（BMI）对绝经前后Luminal型乳腺癌预后的影响。方法回顾性收集四川省肿瘤医院2005-2010年收治的298例女性原发Luminal型乳腺癌病例资料并进行随访,中位随访时间为39个月。将病例根据绝经状态分层,采用COX比例风险模型分析不同BMI（BMI〈23.0 kg/m^2和BMI≥23.0 kg/m^2）对乳腺癌病例无病生存期（DFS）的影响。结果绝经前和绝经后Luminal型乳腺癌患者的平均BMI分别为（22.77±2.67）kg/m^2和（24.47±3.63）kg/m^2,差异有统计学意义（P〈0.001）,BMI〈23.0 kg/m^2和BMI≥23.0 kg/m^2的绝经前Luminal型乳腺癌患者的5年无病生存率分别为78.9%和60.7%（P=0.036）,BMI≥23 kg/m2可显著增加绝经前Luminal型乳腺癌复发转移的风险（调整HR=2.451,95%CI：1.100-5.459）,BMI对绝经后Luminal型乳腺癌DFS的影响无统计学意义。结论高BMI是影响绝经前Luminal型乳腺癌预后的不良因素。Objective The study aimed to detect the associations between body mass index（BMI） and the disease free survivals（DFS） among premenopausal and postmenopausal luminal breast cancer. Methods Clinicopathological and follow-up data（the median follow-up time is 39.0 months） of 298 primary luminal breast cancer patients treated at the Cancer Hospital of Sichuan Province from 2005 to 2010 were collected and divided into two groups according to menopausal status. COX proportional hazards model was used to explore the associations between BMI（BMI〈23.0kg/m^2 and BMI ≥23.0kg/m^2） and DFS among pre- and postmenopausal patients respectively. Results The median BMI of premenopausal and postmenopausal Luminal breast cancer patients was 22.77±2.67kg/m^2 and 24.47±3.63kg/m^2respectively（P〈0.001）. The 5 year DFS of BMI〈23.0kg/m^2 and BMI≥23kg/m^2 premenopausal patients were 78.9% and 60.7% respectively（P=0.036）. After adjustment for age,pathological type,TNM stage and treatment, BMI ≥23kg/m^2 was associated with deceased DFS among premenopausal luminal patients（adjusted HR=2.451, 95% CI： 1.100 -5.459）. No association between BMI and DFS of postmenopausal luminal patients was found.Conclusion High BMI was associated with an increased risk of recurrence or metastasis among premenopausal luminal breast cancer patients.

关 键 词：乳腺肿瘤 预后 体重指数 分子亚型 绝经状态 

分 类 号：R181.32[医药卫生—流行病学]