蜘蛛香化学成分研究  

Chemical constituents from rhizomes of Valeriana jatamansi

作　　者：雍妍 黄青[1] 王茹静[1] 李鸿翔[1] 张海[1] 冯五文 殷子晴[1] 刘宇[1] 伏航漪 谭玉柱[1] 董小萍[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家实验室培育基地,四川成都611137

出　　处：《中草药》2015年第23期3466-3470,共5页Chinese Traditional and Herbal Drugs

基　　金：国家基础科学人才培养基金项目(J13100340-11);四川省教育厅重点项目(15ZA0093);成都中医药大学科技发展基金(ZRQN1440)

摘　　要：目的研究蜘蛛香Valeriana jatamansi根的化学成分。方法药材采用乙醇渗漉提取,利用ODS反相柱、硅胶柱、Sephadex LH-20等色谱技术进行提取分离,根据波谱分析鉴定化合物结构。结果从蜘蛛香根75%乙醇提取物中分离得到13个化合物,分别鉴定为prinsepoil(1)、8-羟基松脂醇(2)、松脂醇(3)、2,5-methanocyclopenta-1,3-dioxin-7-ol(4)、松柏醛(5)、vibutinal(6)、缬草醛(7)、11-ethoxyviburtinal(8)、5-羟甲基糠醛(9)、松脂素-4′-O-β-D-吡喃葡萄糖苷(10)、(7S,8R)-dehydroconiferyl alcohol-8,5′-dehydroconiferyl aldehyde-4-O-β-D-glucopyranoside(11)、厚朴酚(12)、胡萝卜苷(13)。结论化合物11、12为首次从败酱科植物中分离得到,5、6为首次从缬草属植物中分离得到,9、10为首次从该植物中分离得到。Objective To investigate the chemical constituents from the rhizomes of Valeriana jatamansi. Methods The ethanol percolation extraction was isolated and purified by ODS column, silica gel column, and Sephadex LH-20 chromatography. All compounds were identified on the basis of spectral analysis. Results Thirteen compounds were isolated from the rhizomes of V. jatamansi and identified as prinsepoil（1）, 8-hydroxypinoresinol（2）, pinoresinol（3）, 2,5-Methanocyclopenta-1,3-dioxin-7-ol（4）, 3-（4-hydroxy-3-methoxyphenyl）-propenal（5）, vibutinal（6）, baldrinal（7）, 11-ethoxyviburtinal（8）, 5-hydroxymethyl furfural（9）, pinoresinol-4′-O-β-D-glucoside（10）,（7S,8R）-dehydroconiferyl alcohol-8,5′-dehydroconiferyl aldehyde-4-O-β-D-glucopyranoside（11）, magnolol（12）, and daucosterol（13）. Conclusion Compounds 11 and 12 are isolated from the plants in Valerianaceae for the first time, compounds 5 and 6 are isolated from the plants of Valeriana L. for the first time, and compounds 9 and 10 are isolated from this plant for the first time.

关 键 词：蜘蛛香 4-羟基-3-甲氧基肉桂醛 5-羟甲基糠醛 松脂素-4′-O-β-D-吡喃葡萄糖苷 厚朴酚 

分 类 号：R284.1[医药卫生—中药学]