2型糖尿病认知障碍及海马体积与血糖水平关系研究  

THE RELATIONSHIP BETWEEN COGNITIVE IMPAIRMENT,HIPPOCAMPAL VOLUME AND DIFFERENT LEVELS OF BLOOD GLUCOSE IN TYPE 2 DIABETES

作　　者：韦云飞[1] 江文宇[2] 林卫[2] 吴娟[2] 杨秀塔[2] 朱希[2] 张延玲[2] 

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021 [2]广西壮族自治区江滨医院卒中单元

出　　处：《广西医科大学学报》2015年第5期725-728,共4页Journal of Guangxi Medical University

基　　金：广西壮族自治区科技厅科技攻关与新产品试制资助项目(No.桂科攻0993003A-21)

摘　　要：目的:探讨不同血糖水平对2型糖尿病(T2DM)整体认知功能、认知功能域、海马体积的影响。方法:对178例无合并脑血管病变的T2DM患者进行认知功能的测评、海马体积测定,比较不同血糖水平组间认知功能及海马体积差异。严格控制血糖,随访1年,复测认知功能及海马体积,比较治疗前后两者的改变情况。结果:1T2DM组与对照组的认知功能差异有统计学意义(P<0.01),其视空间、语言、注意力、延迟回忆等方面显著下降(P<0.01);2不同血糖控制水平认知功能域的差异有统计学意义(P<0.05),而血糖控制良好者语言、延迟回忆也显著减退(P<0.05);3T2DM组海马体积小于对照组,血糖控制不良亚组左侧海马体积显著缩小(P<0.01)。结论:T2DM具有独立于脑血管病的认知功能损害,尤其是血糖控制不良者;T2DM认知功能损害与海马体积改变相关。Objective：To explore the influence of different levels of blood glucose in type 2 diabetes mellitus （T2DM） on the cognitive function, cognitive domain function and hippocampal volume. Methods：Monitored 178 patients with T2DM without cerebrovascular diseases, and compared cognitive differences and hipp-ocampal volume in different levels of blood glucose groups. Patients with strict control of blood glucose were followed up for one year. Cognitive function and hippocampal volume were compared pre- and post-treatment. Results. ①The visual-spatial, language, attention and delayed recall were significantly declined in T2DM than in the control（ P〈0.01）. ② Differences between cognitive domain function of different levels of blood glucose were statistical significant（ P〈0.05）. ③T2DM hippo-campal volume was less than the normal control group, the left hippocampal volume in the blood sugar uncontrolled group reduced significantly. Conclusion：Cognitive dysfunction existed in T2DM before cerebrovascular damages, especially in patients with uncontrolled blood sugar values. T2DM cognitive impairment associated with changes of hip-pocampal volume.

关 键 词：2型糖尿病 认知障碍 海马体积 

分 类 号：R587.1[医药卫生—内分泌]