低强度脊髓神经刺激对心房电生理性质的影响  

Effects of low-level spinal cord stimulation on atrial electrophysiological characters

作　　者：周丽平[1] 余锂镭[1] 王松云[1] 王卓[1] 黄兵[1] 廖凯[1] 萨仁高娃[1] 陈明鲜 江洪[1] 

机构地区：[1]武汉大学人民医院心内科,湖北武汉430060 [2]中南大学湘雅二医院心内科,湖南长沙410011

出　　处：《中国心脏起搏与心电生理杂志》2015年第6期558-561,共4页Chinese Journal of Cardiac Pacing and Electrophysiology

基　　金：国家自然科学基金资助(No.81270339);湖北省自然科学基金项目资助(No.2013CFB302);中央高校基本科研业务费专项资金资助(No.2042015kf0187)

摘　　要：目的研究低强度脊髓神经刺激（SCS）对心房电生理性质的影响。方法12只成年家犬随机分为SCS组（n=6）和对照组（n=6），以戊巴比妥钠麻醉，在左上肺静脉、右上肺静脉、左下肺静脉、右下肺静脉、左房、右房位点缝置多电极导管，SCS组在T1—T5脊髓节段放置刺激电极并给予SCS1h，对照组放置刺激导线但不给予刺激。分别在基础水平和1h后，心房基础起搏下，依次在心房和肺静脉各位点不应期内发放40ms的高频刺激测定心房颤动（简称房颤）阈值（AF—TH），用S1S2程序刺激法测定心房有效不应期（ERP）和房颤易颤窗口（WOV）。结果SCS组1h后与基础水平比较，心房和肺静脉各位点AF-TH增高，ERP延长，WOV减小（P均〈0．05）。SCS组1h后较对照组1h后AF—TH增高，ERP延长，WOV减小（P均〈0．05）。对照组基础水平与1h后各指标无变化。结论SCS可显著改变心房电生理性质，抑制房颤可诱导性。Objective To investigate the effect of low-level spinal cord stimulation on atrial electrophysialogical characters. Methods Twelve pentobarbital anesthetized dogs were randomly divided into the SCS group （ n = 6） and the control group（n=6）. Catheters were sutured at multiple atrial and pulmonary vein sites. In 6 dogs of SCS group, SCS was delivered to to the spinal at T1-T5 level via wire electrodes. At baseline and 1 h of SCS, high frequency stimulation （HFS） was delivered 2 ms after atrial pacing to determine the AF threshold （AF-TH） at each site, and the effective refractory period （ERP） and window of vulnerability （WOV） for AF were also determined. Results 1 h of SCS induced a significant increase of AF-TH, prolongation of ERP and decrease of WOV. Conclusion SCS can significantly affect atrial electrophysiological characters and suppress AF inducibility. [ Chinese Journal of Cardiac Pacing and Electrophysiology,2015,29 （6） ：558-561]

关 键 词：心血管病学 脊髓神经刺激 自主神经系统 心房颤动 电生理性质 

分 类 号：R541.75[医药卫生—心血管疾病] R331.38[医药卫生—内科学]